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Gene Dmel\E(w^a)

General Information
Symbol	Dmel\E(wa)	Species	D. melanogaster
Name	Enhancer of white-apricot	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0000607
Gene Model Status	Unannotated	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)		Recombination map	2-105.1
Cytogenetic map	60B1-60B10	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Enhancer of white-apricot is referred to in FlyBase by the symbol Dmel\E(wa) (FBgn0000607). It is a gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	E(wa): Enhancer of white-apricot Heterozygote dilutes wa to pale yellow. Homozygote with wa is white. Enhances wa1 and wa4. Also enhances wSp55 and wh (Birchler, 1986, Genetics 113: s47) but not wa2, wa3, wbf, wBwx, wcf, wch, wco, wcol, we, or wsp; enhances phenotype of wa1/wbf. No effect on eye color in presence of w+; and no interaction with other eye-color mutants. Enhancement dominant to two doses of the normal allele in wa/bw+Y;E(wa)/+. Homozygous males sterile; homozygous females partially fertile. RK3.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B1-60B10   Left limit from complementation mapping against Tp(?;2)E(wa)XP3 (FBrf0051917) Right limit from non-inclusion within Df(2R)Px1 (FBrf0051917)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-105.1
Left of (cM)	sp
Right of (cM)	px
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage E(wa)XP1 E(wa)XP3 E(wa)XP40 Sterility Allele female sterile E(wa)1 Phenotype manifest in Allele
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of E(wa) Class Mutagen Stocks Known lesion E(wa)1 antimorphic allele - genetic evidence spontaneous 2 -- E(wa)R2 amorphic allele - genetic evidence 0 -- E(wa)R1 hypomorphic allele - genetic evidence 0 -- E(wa)XP14 spontaneous 0 -- E(wa)XP1 loss of function allele gamma ray 0 Yes E(wa)XP3 loss of function allele gamma ray 0 -- E(wa)XP40 loss of function allele gamma ray 0 Yes
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of E(wa) Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Duplicated in	Dp(2;Y)bw+ (Peng and Mount, 1990)
Not disrupted in	Df(2R)Px1 (Peng and Mount, 1990) Df(2R)spMP (Peng and Mount, 1990) In(2LR)Px4 (Peng and Mount, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions E(wa) allele Gene References E(wa)1 w (Mount et al., 1988, Birchler and Hiebert, 1989, Rabinow and Birchler, 1990) unspecified w
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000607
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	1024 Dp(2;Y)bw+/y1 wa; E(wa)1/CyO
Kyoto	106171 Dp(2;Y)bw+/y1 wa; E(wa)1/CyO
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49111
Antibody Information
Other Information
Discoverer
	Scandlyn.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	E(wa) gene product influences the activity of downstream copia long terminal repeat in 3' end formation. (Peng and Mount, 1990) Mutations at the E(wa) modify the wa phenotype. Effects were determined in pairwise combinations and found to be additive or epistatic. Mutant alleles are dominant. (Rabinow and Birchler, 1990) E(wa) strongly interacts with w alleles that result from the insertion of a transposable element. (Birchler and Hiebert, 1989) All w alleles responsive to E(wa) are associated with transposable element insertions into the transcribed region. (Mount et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000607 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49111
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	E(wa)
Name Synonym	Enhancer of white-apricot
Secondary FlyBase IDs
References ( 10 )
Research paper	Kurkulos et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88: 3038--3042 Polyadenylation in copia requires unusually distant upstream sequences. [FBrf0054964] Peng and Mount, 1990, Genetics 126: 1061--1069 Characterization of enhancer-of-white-apricot in Drosophila melanogaster. [FBrf0051917] Rabinow and Birchler, 1990, Genet. Res. (Camb.) 55: 141--151 Interactions among modifiers of retrotransposon-induced alleles of the white locus of Drosophila melanogaster. [FBrf0051869] Birchler and Hiebert, 1989, Genetics 122: 129--138 Interaction of the Enhancer of white-apricot with transposable element alleles at the white locus in Drosophila melanogaster. [FBrf0049880] Mount et al., 1988, Genetics 118: 221--234 Partial revertants of the transposable element-associated suppressible allele white-apricot in Drosophila melanogaster: Structures and responsiveness to genetic modifiers. [FBrf0048200] Von Halle, 1969, D. I. S. 44: 119 Pursuing the Enhancer of white-apricot. [FBrf0063943]
Abstract	Peng and Mount, 1989, A. Dros. Res. Conf. 30: 41 The identification and characterization of genetic modifiers of white-apricot. [FBrf0066340] Birchler, 1986, Genetics 113(1/2): s47 Dominant genetic enhancers interact with transposable element insertion mutants at the white locus in Drosophila. [FBrf0044510]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]
Thesis	Reed, 1992, Ph.D. Thesis, University of Cambridge, England: 292pp The genetic analysis of endoreduplication in Drosophila melanogaster. [FBrf0064297]