Katsube, T., Hashimoto, N., Sasaki, Y., Yamashita, A., Takahisa, M., Ueda, R., Togashi, S. (2001). Genomic organization, transcription start sites, and chromosomal location of the Drosophila cortactin gene.  Genes & Genet. Systems 76(2): 65--70.

FBrf0136939

Research paper

An actin filament binding protein cortactin was initially identified as a major phosphotyrosine-containing protein in v-Src-transformed chicken embryo fibroblast cells. The mouse, human, and Drosophila homologs were independently identified as a signaling molecule involved in a mitogenic response, as a product of a putative oncogene EMS1, and as a molecule interacting with a scaffolding protein ZO-1, respectively. In this report, we describe the cloning of the Drosophila cortactin gene, which consists of four exons and three introns, covering 3 kilobases in length. All exon-intron junctions are well matched with the GT/AG consensus sequence. S1 nuclease mapping revealed one major and several minor transcription start sites. The cytological location of the Drosophila cortactin gene is between chromosome segments 93B3 and 93B7.