FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cell surface receptor signaling pathway ID (Ontology) GO:0007166 (Gene Ontology)
Definition The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Also Known As "cell surface receptor linked signal transduction" ; "cell surface receptor linked signaling pathway" ; "cell surface receptor linked signalling pathway"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      37
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 cell surface receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       3     37
     involved_in | cell surface receptor signaling pathway       --      37
Spanning Tree (Parents/Children)
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cell communication______________
cellular process________________|
signaling_______________________|
regulation of cellular process__|
cellular response to stimulus___|
                                signal transduction
                                 |__cell surface receptor signaling pathway  809 rec.
                                     |__adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
                                     |__apolipoprotein A-I-mediated signaling pathway
                                     |   |__regulation of apolipoprotein A-I-mediated signaling pathway(+)
                                     |__beta-arrestin-dependent dopamine receptor signaling pathway
                                     |__brassinosteroid mediated signaling pathway
                                     |   |__regulation of brassinosteroid mediated signaling pathway(+)
                                     |__CD27 signaling pathway
                                     |__CD40 signaling pathway
                                     |   |__regulation of CD40 signaling pathway(+)
                                     |__cell surface receptor signaling pathway involved in heart development
                                     |   |__fibroblast growth factor receptor signaling pathway involved in heart development
                                     |   |__Notch signaling involved in heart development(+)
                                     |   |__semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
                                     |   |__smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                     |   |__Wnt signaling pathway involved in heart development(+)
                                     |__cell surface receptor signaling pathway via STAT 47 rec.
                                     |   |__cell surface receptor signaling pathway via JAK-STAT(+) 46 rec.
                                     |   |__regulation of receptor signaling pathway via STAT(+) 39 rec.
                                     |__chemical synaptic transmission, postsynaptic 4 rec.
                                     |   |__excitatory postsynaptic potential(+) 4 rec.
                                     |   |__inhibitory postsynaptic potential(+)
                                     |__collagen-activated signaling pathway
                                     |   |__collagen-activated tyrosine kinase receptor signaling pathway
                                     |__cytokine-mediated signaling pathway 36 rec.
                                     |   |__adiponectin-activated signaling pathway 1 rec.
                                     |   |__chemokine-mediated signaling pathway(+)
                                     |   |__ciliary neurotrophic factor-mediated signaling pathway
                                     |   |__erythropoietin-mediated signaling pathway
                                     |   |__granulocyte colony-stimulating factor signaling pathway 1 rec.
                                     |   |__granulocyte-macrophage colony-stimulating factor signaling pathway
                                     |   |__interferon-mediated signaling pathway(+)
                                     |   |__interleukin-1-mediated signaling pathway(+)
                                     |   |__interleukin-2-mediated signaling pathway(+)
                                     |   |__interleukin-3-mediated signaling pathway
                                     |   |__interleukin-4-mediated signaling pathway(+)
                                     |   |__interleukin-5-mediated signaling pathway
                                     |   |__interleukin-6-mediated signaling pathway(+)
                                     |   |__interleukin-7-mediated signaling pathway
                                     |   |__interleukin-8-mediated signaling pathway
                                     |   |__interleukin-9-mediated signaling pathway
                                     |   |__interleukin-10-mediated signaling pathway
                                     |   |__interleukin-11-mediated signaling pathway
                                     |   |__interleukin-12-mediated signaling pathway
                                     |   |__interleukin-13-mediated signaling pathway
                                     |   |__interleukin-15-mediated signaling pathway
                                     |   |__interleukin-17-mediated signaling pathway(+)
                                     |   |__interleukin-17A-mediated signaling pathway
                                     |   |__interleukin-18-mediated signaling pathway(+)
                                     |   |__interleukin-19-mediated signaling pathway
                                     |   |__interleukin-20-mediated signaling pathway
                                     |   |__interleukin-21-mediated signaling pathway
                                     |   |__interleukin-22-mediated signaling pathway
                                     |   |__interleukin-23-mediated signaling pathway
                                     |   |__interleukin-27-mediated signaling pathway(+)
                                     |   |__interleukin-32-mediated signaling pathway
                                     |   |__interleukin-33-mediated signaling pathway
                                     |   |__interleukin-34-mediated signaling pathway
                                     |   |__interleukin-35-mediated signaling pathway(+)
                                     |   |__Kit signaling pathway(+)
                                     |   |__leptin-mediated signaling pathway(+)
                                     |   |__macrophage colony-stimulating factor signaling pathway(+)
                                     |   |__macrophage migration inhibitory factor signaling pathway(+)
                                     |   |__oncostatin-M-mediated signaling pathway
                                     |   |__prolactin signaling pathway(+)
                                     |   |__regulation of cytokine-mediated signaling pathway(+) 14 rec.
                                     |   |__tumor necrosis factor-mediated signaling pathway(+) 29 rec.
                                     |__enzyme-linked receptor protein signaling pathway 353 rec.
                                     |   |__cell surface receptor protein serine/threonine kinase signaling pathway(+) 94 rec.
                                     |   |__cell surface receptor protein tyrosine kinase signaling pathway(+) 254 rec.
                                     |   |__cell surface receptor protein tyrosine phosphatase signaling pathway 2 rec.
                                     |   |__leukemia inhibitory factor signaling pathway(+)
                                     |   |__receptor guanylyl cyclase signaling pathway 12 rec.
                                     |__extrinsic apoptotic signaling pathway 8 rec.
                                     |   |__B cell receptor apoptotic signaling pathway
                                     |   |__death-inducing signaling complex assembly(+)
                                     |   |__extrinsic apoptotic signaling pathway in absence of ligand(+) 1 rec.
                                     |   |__extrinsic apoptotic signaling pathway via death domain receptors(+) 3 rec.
                                     |   |__fibroblast growth factor receptor apoptotic signaling pathway
                                     |   |__regulation of extrinsic apoptotic signaling pathway(+) 4 rec.
                                     |   |__ripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                     |__Fas signaling pathway
                                     |   |__regulation of Fas signaling pathway(+)
                                     |__glutamate receptor signaling pathway 6 rec.
                                     |   |__G protein-coupled glutamate receptor signaling pathway(+) 3 rec.
                                     |   |__ionotropic glutamate receptor signaling pathway(+) 3 rec.
                                     |   |__regulation of glutamate receptor signaling pathway(+)
                                     |__immune response-regulating cell surface receptor signaling pathway 3 rec.
                                     |   |__Fc receptor signaling pathway(+)
                                     |   |__immune response-activating cell surface receptor signaling pathway(+) 3 rec.
                                     |   |__immune response-inhibiting cell surface receptor signaling pathway(+)
                                     |   |__immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(+)
                                     |__integrin-mediated signaling pathway 14 rec.
                                     |   |__regulation of integrin-mediated signaling pathway(+) 3 rec.
                                     |__lipopolysaccharide-mediated signaling pathway 3 rec.
                                     |   |__regulation of lipopolysaccharide-mediated signaling pathway(+)
                                     |__netrin-activated signaling pathway 3 rec.
                                     |   |__regulation of netrin-activated signaling pathway(+) 1 rec.
                                     |__neuropilin signaling pathway
                                     |   |__VEGF-activated neuropilin signaling pathway(+)
                                     |__neurotrophin signaling pathway 2 rec.
                                     |   |__nerve growth factor signaling pathway 1 rec.
                                     |   |__neurotrophin TRK receptor signaling pathway(+) 1 rec.
                                     |__Norrin signaling pathway
                                     |__Notch signaling pathway 106 rec.
                                     |   |__Notch receptor processing, ligand-dependent 4 rec.
                                     |   |__Notch signaling involved in heart development(+)
                                     |   |__Notch signaling pathway involved in arterial endothelial cell fate commitment
                                     |   |__Notch signaling pathway involved in camera-type eye photoreceptor fate commitment
                                     |   |__Notch signaling pathway involved in forebrain neuroblast division
                                     |   |__Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment
                                     |   |__Notch signaling pathway involved in somitogenesis(+)
                                     |   |__positive regulation of transcription of Notch receptor target
                                     |   |__regulation of Notch signaling pathway(+) 89 rec.
                                     |__positive regulation of integrin activation by cell surface receptor linked signal transduction
                                     |__purinergic nucleotide receptor signaling pathway 2 rec.
                                     |   |__G protein-coupled purinergic nucleotide receptor signaling pathway
                                     |   |__G protein-coupled purinergic receptor signaling pathway(+) 2 rec.
                                     |__reelin-mediated signaling pathway
                                     |__Roundabout signaling pathway 6 rec.
                                     |   |__regulation of Roundabout signaling pathway(+) 1 rec.
                                     |   |__Roundabout signaling pathway involved in axon guidance
                                     |   |__Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell
                                     |   |__termination of Roundabout signal transduction
                                     |__semaphorin-plexin signaling pathway 11 rec.
                                     |   |__regulation of semaphorin-plexin signaling pathway(+) 2 rec.
                                     |   |__semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
                                     |   |__semaphorin-plexin signaling pathway involved in neuron projection guidance(+)
                                     |   |__semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
                                     |   |__semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance
                                     |__smoothened signaling pathway 104 rec.
                                     |   |__ciliary receptor clustering involved in smoothened signaling pathway
                                     |   |__mesenchymal smoothened signaling pathway involved in prostate gland development
                                     |   |__regulation of smoothened signaling pathway(+) 96 rec.
                                     |   |__smoothened signaling pathway involved in dorsal/ventral neural tube patterning(+)
                                     |   |__smoothened signaling pathway involved in lung development
                                     |   |__smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
                                     |   |__smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
                                     |   |__smoothened signaling pathway involved in ventral spinal cord patterning(+)
                                     |__Toll signaling pathway 56 rec.
                                     |   |__regulation of Toll signaling pathway(+) 43 rec.
                                     |__urokinase plasminogen activator signaling pathway
                                     |__Wnt signaling pathway 149 rec.
                                         |__canonical Wnt signaling pathway(+) 131 rec.
                                         |__non-canonical Wnt signaling pathway(+) 9 rec.
                                         |__regulation of Wnt signaling pathway(+) 121 rec.
                                         |__Wnt signaling pathway involved in forebrain neuroblast division
                                         |__Wnt signaling pathway involved in heart development(+)
                                         |__Wnt signaling pathway involved in somitogenesis
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Synonyms
  • "cell surface receptor linked signal transduction" EXACT
    "cell surface receptor linked signaling pathway" EXACT
    "cell surface receptor linked signalling pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-73887 "Death Receptor Signaling"