FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term intracellular signal transduction ID (Ontology) GO:0035556 (Gene Ontology)
Definition The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.[ ISBN:3527303782 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     129
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 intracellular signal transduction (all annotations which use CV term, excluding "NOT" statements)     129
     involved_in | intracellular signal transduction     129
Spanning Tree (Parents/Children)
Only view relationship:
cell communication______________
cellular process________________|
signaling_______________________|
regulation of cellular process__|
cellular response to stimulus___|
                                signal transduction
                                 |__intracellular signal transduction  785 rec.
                                     |__cell cycle checkpoint signaling 63 rec.
                                     |   |__DNA integrity checkpoint signaling(+) 44 rec.
                                     |   |__meiotic cell cycle checkpoint signaling(+) 4 rec.
                                     |   |__mitotic cell cycle checkpoint signaling(+) 45 rec.
                                     |   |__regulation of cell cycle checkpoint(+) 6 rec.
                                     |   |__spindle checkpoint signaling(+) 14 rec.
                                     |__chloroplast-nucleus signaling pathway
                                     |__endoplasmic reticulum unfolded protein response 24 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__IRE1-mediated unfolded protein response(+) 4 rec.
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 4 rec.
                                     |__ER-nucleus signaling pathway 7 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__ER overload response(+)
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__SREBP signaling pathway(+) 5 rec.
                                     |__hippo signaling 101 rec.
                                     |   |__regulation of hippo signaling(+) 94 rec.
                                     |__hypoxia-inducible factor-1alpha signaling pathway
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |__intracellular receptor signaling pathway 32 rec.
                                     |   |__blue light signaling pathway 1 rec.
                                     |   |__cytoplasmic pattern recognition receptor signaling pathway(+) 9 rec.
                                     |   |__juvenile hormone mediated signaling pathway 5 rec.
                                     |   |__nuclear receptor-mediated signaling pathway(+) 15 rec.
                                     |__intracellular signaling cassette 428 rec.
                                     |   |__calcium-mediated signaling(+) 34 rec.
                                     |   |__cAMP/PKA signal transduction(+) 8 rec.
                                     |   |__canonical NF-kappaB signal transduction(+) 13 rec.
                                     |   |__integrated stress response signaling(+) 2 rec.
                                     |   |__MAPK cascade(+) 167 rec.
                                     |   |__nitric oxide mediated signal transduction(+) 5 rec.
                                     |   |__non-canonical NF-kappaB signal transduction(+) 3 rec.
                                     |   |__phosphatidylinositol 3-kinase/protein kinase B signal transduction(+) 33 rec.
                                     |   |__phospholipase C/protein kinase C signal transduction
                                     |   |__SMAD protein signal transduction(+) 11 rec.
                                     |   |__small GTPase-mediated signal transduction(+) 194 rec.
                                     |__intrinsic apoptotic signaling pathway 27 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to DNA damage(+) 15 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(+) 7 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to hypoxia(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to nitrosative stress(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to oxidative stress(+) 2 rec.
                                     |   |__regulation of intrinsic apoptotic signaling pathway(+) 9 rec.
                                     |__mitochondria-nucleus signaling pathway
                                     |__osmosensory signaling pathway
                                     |   |__osmosensory signaling pathway via Sho1 osmosensor
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |__phosphatidylinositol-mediated signaling 9 rec.
                                     |__phosphorelay signal transduction system
                                     |   |__ethylene-activated signaling pathway(+)
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |   |__regulation of phosphorelay signal transduction system(+)
                                     |__protein kinase C signaling 1 rec.
                                     |   |__regulation of protein kinase C signaling(+)
                                     |__RAM/MOR signaling
                                     |__regulation of intracellular signal transduction 445 rec.
                                     |   |__negative regulation of intracellular signal transduction(+) 153 rec.
                                     |   |__positive regulation of intracellular signal transduction(+) 236 rec.
                                     |   |__regulation of calcium-mediated signaling(+) 14 rec.
                                     |   |__regulation of cAMP/PKA signal transduction(+) 7 rec.
                                     |   |__regulation of canonical NF-kappaB signal transduction(+) 11 rec.
                                     |   |__regulation of cell cycle checkpoint(+) 6 rec.
                                     |   |__regulation of cytoplasmic pattern recognition receptor signaling pathway(+) 2 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 4 rec.
                                     |   |__regulation of hippo signaling(+) 94 rec.
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |   |__regulation of intracellular steroid hormone receptor signaling pathway(+) 10 rec.
                                     |   |__regulation of intrinsic apoptotic signaling pathway(+) 9 rec.
                                     |   |__regulation of MAPK cascade(+) 144 rec.
                                     |   |__regulation of nitric oxide mediated signal transduction(+)
                                     |   |__regulation of non-canonical NF-kappaB signal transduction(+) 1 rec.
                                     |   |__regulation of peroxisome proliferator activated receptor signaling pathway(+)
                                     |   |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction(+) 28 rec.
                                     |   |__regulation of phosphorelay signal transduction system(+)
                                     |   |__regulation of protein kinase C signaling(+)
                                     |   |__regulation of retinoic acid receptor signaling pathway(+)
                                     |   |__regulation of signal transduction by p53 class mediator(+) 5 rec.
                                     |   |__regulation of SMAD protein signal transduction(+) 8 rec.
                                     |   |__regulation of small GTPase mediated signal transduction(+) 96 rec.
                                     |   |__regulation of SREBP signaling pathway(+) 1 rec.
                                     |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                     |   |__regulation of thyroid hormone receptor signaling pathway(+)
                                     |   |__regulation of TOR signaling(+) 67 rec.
                                     |   |__regulation of vitamin D receptor signaling pathway(+)
                                     |__signal transduction by p53 class mediator 11 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator(+) 5 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |   |__regulation of signal transduction by p53 class mediator(+) 5 rec.
                                     |__signal transduction in response to DNA damage 42 rec.
                                     |   |__DNA damage checkpoint signaling(+) 38 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator(+) 5 rec.
                                     |   |__DNA damage response, signal transduction resulting in transcription
                                     |__stress-activated protein kinase signaling cascade 7 rec.
                                     |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                     |   |__stress-activated MAPK cascade(+) 5 rec.
                                     |__TOR signaling 82 rec.
                                         |__regulation of TOR signaling(+) 67 rec.
                                         |__TORC1 signaling(+) 60 rec.
                                         |__TORC2 signaling(+) 8 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a signal transduction
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "intracellular signal transduction pathway" NARROW
    "intracellular signaling cascade" RELATED
    "intracellular signaling pathway" RELATED
    "signal transmission via intracellular cascade" NARROW
Secondary IDs
hide External Crossreferences & Linkouts