FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(2L)p35-C2
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General Information
Symbol
Df(2L)p35-C2
Species
D. melanogaster
Name
FlyBase ID
FBab0045956
Feature type
chromosomal_deletion
Also Known As
Df(p35)C2, DfC2, Df(Cdk5α)C2
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{lacW}nmdk10909
(Connell-Crowley et al., 2007)
P{lacW}P100
(Connell-Crowley et al., 2007)
Mutagen
P-element activity
(Connell-Crowley et al., 2007)
Class of aberration (relative to wild type)
chromosomal_deletion
(Connell-Crowley et al., 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Connell-Crowley et al., 2007)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

No Cdk5α transcript is detectable by in situ hybridization in Df(2L)p35-C2 homozygous embryos.

(Connell-Crowley et al., 2007)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Cdk5α
(Connell-Crowley et al., 2007)
CG4968
(Connell-Crowley et al., 2007)
Sph35
(Connell-Crowley et al., 2007)
Partially deleted
nmd
(Connell-Crowley et al., 2007)
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Cdk5α20C/Df(2L)p35-C2 transheterozygous adults display significantly reduced adult lifespan and aged adults display more severe neurodegenerative phenotype (compromised tissue integrity particularly in the mushroom body) relative to control flies of comparable physiological age (= at equivalent stage of population mortality) but this effect is not due to either increased apoptosis or necrosis. The aged mutant adults however accumulate more autophagosomal organelles relative to controls. Cdk5α20C/Df(2L)p35-C2 adult also display significantly reduced survival rate upon starvation.

    (Trunova and Giniger, 2012)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Df(2L)p35-C2
    Df(Cdk5α)C2
    (Wodrich et al., 2024, Shukla et al., 2019)
    Df(Cdk5α)C2
    (Wodrich et al., 2024)
    Df(p35)C2
    (Spurrier et al., 2018, Kang et al., 2012, Connell-Crowley et al., 2007)
    DfC2
    (Shukla et al., 2019, Spurrier et al., 2018, Trunova and Giniger, 2012)
    Name Synonyms
    Secondary FlyBase IDs
      References (7)