FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(2L)Sclg6
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General Information
Symbol
Df(2L)Sclg6
Species
D. melanogaster
Name
FlyBase ID
FBab0047491
Feature type
chromosomal_deletion
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
(Magny et al., 2013)
Class of aberration (relative to wild type)
chromosomal_deletion
(Magny et al., 2013)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Magny et al., 2013)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

The deficiency spans at least the 80kb genomic region between CG13282 and ApepP with an undetermined breakpoint somewhere in the 300kb region between ApepP and CG31784.

(Magny et al., 2013)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)Scl12/Df(2L)Sclg6 adults show significantly more cardiac arrhythmicity compared to control flies.

    (Magny et al., 2013)

    Df(2L)Scl12/Df(2L)Sclg6 animals are viable and fertile. Cardiomyocytes and cardiac ventral longitudinal fibres show a regular arrangement of their sarcomeres in the mutant adults, comparable to those of wild type. No ultrastructural defects in sarcomeric structure or dyads (cellular structure where the plasma membrane is in close apposition to the sarcoplasmic reticulum membrane) are seen in the mutant indirect flight muscles.

    (Magny et al., 2013)

    Df(2L)Scl12/Df(2L)Sclg6 adults show significantly more cardiac arrhythmicity compared to control flies. Cardiac cells show irregular action potentials involving "double" and occasionally failed action potentials. During heart contraction, the Ca[2+] transients show significantly higher amplitudes and steeper decay than those of wild-type controls.

    (Magny et al., 2013)
    NOT in combination with other aberrations

    Homozygous lethal.

    Heterozygous adults do not show any increase in cardiac arrhythmicity compared to wild type.

    (Magny et al., 2013)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Df(2L)Sclg6
    Df(2L)sclg6
    (Magny et al., 2013, Magny et al., 2013)
    Name Synonyms
    Secondary FlyBase IDs
      References (2)