FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(2L)FASNΔ24-23
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General Information
Symbol
Df(2L)FASNΔ24-23
Species
D. melanogaster
Name
FlyBase ID
FBab0047689
Feature type
Also Known As
FASNΔ24-23
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Mutagen
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Remobilization of the chimeric progenitor P-element (P{XP-U}FASNΔ24) present in Df(2L)FASNΔ24, resulting in an imprecise excision that removes an addition 1200bp of the FASN1 gene, including the first methionine codon and the sequence coding half of the KS domain. FASN2 expression is not detected and FASN1 transcript levels are barely detectable.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Lethal at the L1 larval stage. Lethality can be partially rescued by growing flies on a low carbohydrate diet supplemented with butter and egg yolk (as dietary lipid sources); addition of 10% sucrose to this diet results in total lethality at L1 stage.

    For larvae fed a low carbohydrate diet, the size of cells in Df(2L)FASNΔ24-23 clones is slightly reduced compare to neighboring control cells. However, as the sucrose content in the diet increases, a concomitant reduction in the size of cells is observed.

    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (3)