FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Act88F1
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General Information
Symbol
Dmel\Act88F1
Species
D. melanogaster
Name
FlyBase ID
FBal0000267
Feature type
allele
Associated gene
Dmel\Act88F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Fyrberg et al., 1988)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: R28C.

(Fyrberg et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,440,700..15,440,700 [+]
Nucleotide change:

C15440700T

Amino acid change:

R29C | Act88F-PA

Reported amino acid change:

R28C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Fyrberg et al., 1988)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The thick and thin filaments of the indirect flight muscles of homozygous animals have detached posterior ends before 78 hours after puparium formation (APF). After 78 hours APF, hypercontraction of the fibres is initiated from the posterior ends. At eclosion, the fibres show a partial hypercontraction phenotype (one end is detached), and in flies more than 2 days after eclosion, the fibres are hypercontracted.

      (Nongthomba et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weakly induces heat shock proteins.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Act88F1
      Act88FR28C
      (Nongthomba et al., 2003, Vigoreaux, 2001)
      Ifm(3)1
      (Fyrberg et al., 1988, Karlik and Fyrberg, 1985)
      Ifm(3)2
      (Vigoreaux, 2001, Fyrberg et al., 1988, Karlik and Fyrberg, 1985)
      R28C
      (Mogami et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)