FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Act88F4
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General Information
Symbol
Dmel\Act88F4
Species
D. melanogaster
Name
FlyBase ID
FBal0000270
Feature type
allele
Associated gene
Dmel\Act88F
Associated Insertion(s)
Carried in Construct
Also Known As
Ifm(3)7
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(An and Mogami, 1996, Fyrberg et al., 1988)
Mutagen
ethyl methanesulfonate
(An and Mogami, 1996, Karlik and Fyrberg, 1985)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G3884A.

(An and Mogami, 1996)

Amino acid replacement: W356term.

(An and Mogami, 1996, Fyrberg et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:15,441,747..15,441,747 [+]
Nucleotide change:

G15441747A

Amino acid change:

W357term | Act88F-PA

Reported amino acid change:

W356term

Comment:

TGG to TGA

(An and Mogami, 1996, Fyrberg et al., 1988)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
K02065
AAA28322
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes rarely exhibit free myofibril fibres and if present they are cut, fragmented, torn and gapped. Indirect flight muscle fibres are normal in homozygotes and heterozygotes.

      (An and Mogami, 1996)

      Heterozygotes are flightless with a normal wing posture.

      (Homyk and Emerson, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strongly induces heat shock proteins.

      Actin III replaced by a truncated polypeptide of 42kD that is stable and capable of incorporation into myofibrils; actin II reduced in homozygotes. Myofibrils in indirect flight muscles of homozygotes severely deranged; sarcomere structure obliterated; indirect-flight-muscle nuclei enlarged. Skeins of morphologically normal but highly disorganized thick filaments present, but Z discs absent. Thin filaments scarce. Electron dense material of unknown origin seen in sections.

      (Hiromi and Hotta, 1985)

      Wild-type flies transformed with cloned Act88F4 sequence produces both the 42kD and the heat-shock proteins.

      (Hiromi et al., 1986)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Act88F4
      Act88FKM75
      Act88FW356@-2
      (Vigoreaux, 2001)
      Ifm(3)7
      (Fyrberg et al., 1988, Homyk and Emerson, 1988, Karlik and Fyrberg, 1985)
      W356@
      (Mogami et al., 1998, An and Mogami, 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)