FB2026_02 , released June 18, 2026
Allele: Dmel\Actn4
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General Information
Symbol
Dmel\Actn4
Species
D. melanogaster
Name
FlyBase ID
FBal0000278
Feature type
allele
Associated gene
Dmel\Actn
Associated Insertion(s)
Carried in Construct
Also Known As
fliA4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Point mutation.

(Roulier et al., 1992, Fyrberg et al., 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,025,701..2,025,701 [-]
Nucleotide change:

A2025701T

Comment:

An AG to TG mutation in a splice acceptor site.

(Roulier et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Thoracic muscle abnormalities, easily detach from cuticle and readily dissociate into single fibers: Z discs and myofibrillar attachments are disrupted. Epithelial 'tendon' cells are less affected.

      (Fyrberg et al., 1990)

      Homozygotes are flightless with a normal wing posture.

      (Homyk and Emerson, 1988)

      Actn1/Actn4 jumps and flies abnormally when raised at 22oC but normally when raised at 29oC; temperature-sensitive period for this effect in first half of pupal stage.

      (Homyk et al., 1980)

      When raised at low temperature, causes aberrant wing display of courting males.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Actn4, wupAhdp-2 has flightless | dominant phenotype

      (Homyk and Emerson, 1988)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygotes with wupAhdp-2 are flightless.

      (Homyk and Emerson, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Actn4 is rescued by ActnRpS27A.PD

      (Dubreuil and Wang, 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Homyk.

      Separable from: prom2.

      (Sang and Ready, 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Actn4
      fliA4
      (Dubreuil and Wang, 2000)
      fliA4
      (Sang and Ready, 2002, Vigoreaux, 2001, Roulier et al., 1992, Fyrberg et al., 1991, Fyrberg et al., 1990)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)