FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Adhn4
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General Information
Symbol
Dmel\Adhn4
Species
D. melanogaster
Name
FlyBase ID
FBal0000335
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Hollocher and Place, 1987, Woodruff and Ashburner, 1979)

loss of function allele

Mutagen
ethyl methanesulfonate
(Savakis et al., 1986)
Progenitor genotype
AdhD
(Hollocher and Place, 1987)
Cytology
Description

A premature stop codon located 258bp upstream from the boundary between exon 3 and exon 4.

(Micale et al., 2009)

Steady state level of Adh mRNA is greatly reduced.

(Brogna, 1999)

Nucleotide substitution: C312T.

(Chia et al., 1987)

Amino acid replacement: Q83term.

(Chia et al., 1987)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:14,616,650..14,616,650 [+]
Nucleotide change:

C14616650T

Reported nucleotide change:

C312T

Amino acid change:

Q83term | Adh-PC; Q83term | Adh-PE; Q83term | Adh-PF; Q83term | Adh-PH; Q83term | Adh-PI

Reported amino acid change:

Q83term

(Chia et al., 1987)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X04454
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Oviposition sites on standard medium and acetic acid supplement medium are studied.

      (Eisses, 1997)

      Sensitive to pentenol. Not sensitive to pentenone.

      (Garrido and Barbancho, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (18)
      Notes on Origin
      Discoverer

      E.H. Grell.

      Comments
      Comments

      CRM negative.

      No detectable protein.

      (Hollocher and Place, 1987)

      Product does not form active hybrid enzyme.

      (Hollocher and Place, 1987)

      Adhn4 mRNA is only 10% of wild type levels. S1 nuclease protection studies show the processing of the Adhn4 transcript to be normal.

      (Chia et al., 1987)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Adhn4
      (Nelson et al., 2016, Frizzell et al., 2012, Micale et al., 2009, Metzstein and Krasnow, 2006)
      bAdhn4
      (Emans and Eisses, 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (27)