FB2026_02 , released June 18, 2026
Allele: Dmel\Ama-11
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General Information
Symbol
Dmel\Ama-11
Species
D. melanogaster
Name
FlyBase ID
FBal0000448
Feature type
allele
Associated gene
Ama-1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Resistant to α-amanitin. Flies homozygous or heterozygous for Ama-11 and Ama-21 have LD50 to α-amanitin 10-30 times that of wild type. Sensitivity of RNA polymerase II activity to α-amanitin same as wild type.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Ama-11, Ama-21 has chemical resistant phenotype

      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: India population. Isolated from: Malaysia population. Isolated from: Taiwan population.

      Comments
      Comments

      Ama-11 alone sufficient to confer resistance, but in three independent isolations both Ama-11 and Ama-21 present.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ama-11
      Name Synonyms
      Secondary FlyBase IDs
        References (2)