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General Information
Symbol
Dmel\BicC3
Species
D. melanogaster
Name
FlyBase ID
FBal0001137
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Bic-CRU35
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G16045892A

Reported nucleotide change:

G1761A

Amino acid change:

G296R | BicC-PA; G296R | BicC-PB; G176R | BicC-PD

Reported amino acid change:

G296R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G296R.

Amino acid replacement: G295R. Nucleotide substitution: G1761A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A zone along the anterior region of the oocyte shows a significantly higher concentration of microtubules in BicC3/BicC4 egg chambers compared to wild type.

BicC3/BicC4 egg chambers often show incomplete nurse cell dumping. The actin cables that normally restrain the nurse cell nuclei are absent in the mutant egg chambers, and nurse cell nuclei are often seen to have entered the ring canals.

Dominant haplo-insufficiency phenotype, eggs produced have fused dorsal appendages.

Strong BicC allele. BicC3 and BicC5 are the most severe alleles.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Schupbach.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)