FB2020_06, released Dec 22, 2020

Allele: Dmel\BicC3

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General Information
Symbol
Dmel\BicC3
Species
D. melanogaster
Name
FlyBase ID
FBal0001137
Feature type
allele
Associated gene
Dmel\BicC
Associated Insertion(s)
Carried in Construct
Also Known As
Bic-CRU35
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Schupbach and Wieschaus, 1991)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
2L:16,045,892..16,045,892 [+]
Nucleotide change:

G16045892A

Reported nucleotide change:

G1761A

Amino acid change:

G296R | BicC-PA; G296R | BicC-PB; G176R | BicC-PD

Reported amino acid change:

G296R

(Ashburner et al., 1999.10.12, Saffman et al., 1998, Mahone et al., 1997, Mahone et al., 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: G296R.

      (Saffman et al., 1998)

      Amino acid replacement: G295R. Nucleotide substitution: G1761A.

      (Mahone et al., 1995)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A zone along the anterior region of the oocyte shows a significantly higher concentration of microtubules in BicC3/BicC4 egg chambers compared to wild type.

      BicC3/BicC4 egg chambers often show incomplete nurse cell dumping. The actin cables that normally restrain the nurse cell nuclei are absent in the mutant egg chambers, and nurse cell nuclei are often seen to have entered the ring canals.

      (Snee and Macdonald, 2009)

      Dominant haplo-insufficiency phenotype, eggs produced have fused dorsal appendages.

      (Schupbach and Wieschaus, 1991)

      Strong BicC allele. BicC3 and BicC5 are the most severe alleles.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Schupbach.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bic-CRU35
      (Saffman et al., 1998, Rother et al., 1997, Mahone et al., 1995)
      BicC3
      BicCRU35
      (Snee and Macdonald, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)