FlyBase Allele Report: Dmel\bw[V1]

General Information

Symbol

Dmel\bw^V1

Species

D. melanogaster

Name

Variegated

FlyBase ID

FBal0001401

Feature type

allele

Associated gene

Dmel\bw

Associated Insertion(s)

Carried in Construct

Also Known As

Plum

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(2LR)bw^V1

Cytology

Description

Sharply reduced levels of transcript from both the bw⁺ allele in cis with the rearrangement and the bw allele on the homologous second chromosome.

(Henikoff and Dreesen, 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | dominant

visible

(Kadel, 1959)

Phenotype Manifest In

pigment cell

Detailed Description

Statement

Reference

bw^V1 is recessive in D.melanogaster/D.simulans hybrids.

(Goldschmidt, 1999)

Malpighian tubule colour: wild-type. Eye colour: brown; mottled with darker spots that deepen in red color with age. Eye colour: pale orange; dark orange spots, with st¹. Eye colour: pale orange; dark orange spots, with v¹. RK1A.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bw^V1 has visible phenotype, suppressible by Dp(2;2)Su(Pm)

(Kadel, 1959)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Dp(2;2)Su(Pm) suppresses the bw phenotype in bw^V1, leaving only the variegation; Dp(2;2)Su(Pm)/bw^V1 flies have variegated red eyes.

(Kadel, 1959)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (25)

Bloomington

1580

In(2LR)bw^V1, ds^33k bw^V1/SM5

3170

In(2LR)bw^V1, ds^33k l(2)DTS18WF¹ bw^V1/CyO

224

Df(2R)cn87e/In(2LR)bw^V1, ds^33k Adc^b-1 bw^V1

326

In(2L)t, l(2)a¹ bs³/In(2LR)bw^V1, ds^33k bw^V1

3705

T(2;3)CyO-TM9, l(3)DTS4¹/In(2LR)bw^V1, ds^33k bw^V1; H¹

742

Df(2R)rl10a, lt¹ rl^10a cn¹/In(2LR)bw^V1, ds^33k bw^V1

Kyoto

106399

In(2LR)bw^V1, ds^33k bw^V1/SM5

101344

cn¹ bw¹ bgcn^Q52 / bw^V1

105885

S²/In(2LR)bw^V1, ds^33k bw^V1

101501

In(2L)Cy, Duox^Cy / In(2LR)bw^V1, ds^33k bw^V1

105798

Df(2R)cn87e/In(2LR)bw^V1, ds^33k Adc^b-1 bw^V1

106871

Df(2L)dp-79b, dpy^DA cn¹/In(2LR)bw^V1, Adc^b-1 bw^V1

More stocks available...

Notes on Origin

Discoverer

Muller, 1929.

Comments

Extra Y chromosome, as with other variegated browns, suppresses brown color, giving red eye sparsely speckled or splotched with darker spots. Amount of wild-type eye color also responds to fourth-chromosome constitution; 4/C(4) > C(4) = 4/4 > 4/0, with the first approaching wild type and the latter nearly bw (Lindsley and Rokop). Generally lethal homozygous and in combination with other brown-Variegateds. Heterozygotes fully viable and fertile.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

(Goldschmidt, 1999)

bw^V1

bw^V

(Henikoff, 1992, Spradling and Karpen, 1990)

Name Synonyms

Plum

(Kadel, 1959, Morgan, 1947)

Variegated

Secondary FlyBase IDs

References (16)

Report Sections

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