FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cup4
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General Information
Symbol
Dmel\cup4
Species
D. melanogaster
Name
FlyBase ID
FBal0002149
Feature type
allele
Associated gene
Dmel\cup
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Keyes and Spradling, 1997, Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Egg chambers arrest at stage S10. The oldest egg chambers often contain polytene nurse cell nuclear chromatin with high ploidy. cup4 has a dominant effect on meiotic X chromosome segregation.

      (Keyes and Spradling, 1997)

      Abnormalities in follicle cell migration: open ended chorion.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cup4/cup[+] is a suppressor of female sterile | recessive phenotype of Rbp9B

      (Keyes and Spradling, 1997)
      Other
      Statement
      Reference

      Rbp9B, cup4/cup[+] has female semi-fertile phenotype

      (Keyes and Spradling, 1997)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      cup4 has egg chamber phenotype, suppressible by otu[+]/otu11

      (Keyes and Spradling, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous females show a strong phenotypic improvement if they also carry one copy of otu11, allowing egg chamber growth to a later developmental stage with more uniform chromatin morphologies, although they are still sterile. 41% of egg chambers in these females are dicephalic. Rbp9B/Rbp9B cup4/+ females are weakly fertile, with an average of one viable embryo per female.

      (Keyes and Spradling, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cup4
      cupPF21
      Name Synonyms
      Secondary FlyBase IDs
        References (3)