FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\D1
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General Information
Symbol
Dmel\D1
Species
D. melanogaster
Name
FlyBase ID
FBal0002210
Feature type
allele
Associated gene
Dmel\D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Russell et al., 1996)
Progenitor genotype
Caused by aberration
In(3L)D
Cytology
Description

The aberration breakpoint is +2 to +5 kb 5' of the D transcription unit (where 0 indicates the translation start site).

(Sanchez Soriano and Russell, 2000)

Breakpoint maps 5' to the D transcription unit, within approximately 2-5kb of the transcription start site.

(Russell et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      D1/+ individuals have posterior alar lobe deletions.

      (Russell, 2000)

      Exhibits a dominant wing hinge phenotype.

      (Sanchez Soriano and Russell, 2000)

      D1 is lethal over both "Sai" alleles of mirr but other D alleles are viable, implying that this lethality is due to the 69D3-4 breakpoint of the D1 inversion. Dominant late pupal lethal interaction of D1 with eyD is probably not an integral aspect of the D phenotype as D4 and D5/D+;eyD/ey+ flies are viable. Viable when heterozygous with all lethal D alleles, the phenotype is the sum of the two D alleles.

      (Carpenter, 1994)

      Wings extended uniformly at 45o from body axis and elevated 30o above (occasionally sharply downcast and dragging). Alulae missing. Dorsocentrals and some other bristles reduced in number (Sturtevant, 1918; Plunkett, 1926). Head often deformed or split in postvertical region. Halteres turned down. Homozygous lethal. Nearly lethal in combination with eyD (Sobels, Kruijt and Spronk, 1951). Partially suppressed by sc alleles that remove postverticals (sc, sc4, sc6, sc7) but not by others (Df(1)ase-1, sc5) (Sturtevant). Classifiable in triploids. RK2A.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      D1 is an enhancer of visible phenotype of upd1GMR.PB

      (Bach et al., 2003)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      D1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Enhancer of
      Statement
      Reference

      D1 is an enhancer of eye phenotype of upd1GMR.PB

      (Bach et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      D1 is epistatic to Mpe1; Mpe1/D1 flies show the D1 phenotype.

      (Hughes and Shelton, 1980)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (1)
      Stocks (48)
      Notes on Origin
      Discoverer

      Bridges, 3rd Jan. 1915.

      It is possible that the D1 and D3 inversions reflect dominant mutations in the 'Sail' function of mirr (see mirrSaiD1 and mirrSaiD3).

      (Russell, 1999.1.25)
      Comments
      Comments

      There is some uncertainty in the designation of D1, D3 and "D9" as dominant D alleles. The wing phenotype of D3 (a protein null) is similar, if not identical, to D1 when assayed in outcrossed individuals; it is thus possible that the phenotype of D1 itself is not due to changes at the D locus. D protein is ectopically expressed in the wing discs of D1 individuals and reversion of D1 is associated with loss of D expression in the wing disc.

      (Russell, 1999.1.25)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      D
      (Hughes and Shelton, 1980)
      D1
      (Kuzin et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (15)