FlyBase Allele Report: Dmel\Ddc[8]

General Information

Symbol

Dmel\Ddc⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0002257

Feature type

allele

Associated gene

Dmel\Ddc

Associated Insertion(s)

Carried in Construct

Also Known As

Ddcⁿ⁸

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Wright et al., 1981)

Mutagen

ethyl methanesulfonate

(Wright et al., 1982, Wright et al., 1981, Wright et al., 1976)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Wright et al., 1982, Wright et al., 1976)

partially lethal (with Ddc⁵)

(Bishop et al., 1999)

partially lethal (with Ddc^DE1)

(Bishop et al., 1999)

Phenotype Manifest In

axillary sclerite

(Wright et al., 1976)

cuticle

(Wright et al., 1976)

macrochaeta

(Wright et al., 1976)

Detailed Description

Statement

Reference

Ddc⁵/Ddc⁸ and Ddc⁸/Ddc^DE1 flies show partial lethality.

(Bishop et al., 1999)

Ddc^ts1 heterozygotes with Ddc null alleles show temperature-dependent sterility.

(Wright et al., 1981)

Adult escapers of the lethality show prolonged development time and die within 24 hours of eclosion, their bristles are thin and straw coloured, and body does not darken, the wing axillae are melanized similar to the mutant phenotype of sp, the leg joints are melanized similar to a wound reaction, and they walk on their tibia rather than their tarsi, although they are coordinated.

(Wright et al., 1976)

Specific DDC activity of newly eclosed adult CyO/Ddc heterozygotes, as percentage of CyO/+ control: 39.6

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Ddc⁸/Ddc⁵ has partially lethal phenotype, non-suppressible by Tcr⁴⁵

(Bishop et al., 1999)

Ddc^DE1/Ddc⁸ has partially lethal phenotype, non-suppressible by Tcr⁴⁵

(Bishop et al., 1999)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The partial lethality seen in Ddc⁵/Ddc⁸ and Ddc⁸/Ddc^DE1 flies is not substantially rescued by Tcr⁴⁵.

(Bishop et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Wright.

Comments

Alleles of Ddc show intracistronic complementation. Ddc⁵ complements Ddc¹, Ddc², Ddc³, Ddc⁴, Ddc⁵, Ddc⁶ and Ddc⁸, and all complementary combinations involve Ddc⁵ or Ddc⁸.

(Wright et al., 1976)

Certain combinations of Ddc alleles show intragenic complementation.

(Wright et al., 1982)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ddc⁸

Ddcⁿ⁸

(Bishop et al., 1999, Wright et al., 1982, Wright et al., 1981, Wright et al., 1976)

l(2)E143

Name Synonyms

Secondary FlyBase IDs

FBal0042498

References (5)

Report Sections

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