FB2026_02 , released June 18, 2026
Allele: Dmel\dsx15
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General Information
Symbol
Dmel\dsx15
Species
D. melanogaster
Name
FlyBase ID
FBal0003168
Feature type
allele
Associated gene
Dmel\dsx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Mutation falls within DNA binding domain.

(Erdman and Burtis, 1993)

Amino acid replacement: H50Y.

(Erdman and Burtis, 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:7,960,658..7,960,658 [-]
Nucleotide change:

C7960658T

Amino acid change:

H50Y | dsx-PA; H50Y | dsx-PB; H50Y | dsx-PC; H50Y | dsx-PD; H50Y | dsx-PE; H50Y | dsx-PF; H50Y | dsx-PG

Reported amino acid change:

H50Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Erdman and Burtis, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dsx15/dsxGAL4 mutant adult males have ectopic formation of usually female-specific pMN2 neurons; pMN2 neurons are still present in females of this genotype as normal.

      (Kimura et al., 2015)

      XY males show courtship sluggishness when compared to wild type siblings. Aging does not improve the courtship performance. Song pulses are similar to those of dsx+ males, though number and duration of song bouts are much reduced. No sine-song bouts whatsoever are generated by dsx mutants. In elicitation and rejection tests, dsx haplo-X mutants demonstrate an attractiveness that cannot be explained by general enfeeblement, such as inability to reject courtship advances.

      (Villella and Hall, 1996)

      XX dsx15/Df(3R)dsx15 flies do not show any male-specific courtship when paired with mature virgin females. 58% of XY dsx15/Df(3R)dsx15 flies show male-specific courtship when paired with mature virgin females.

      (Taylor et al., 1994)

      Sex specific neuroblasts fail to undergo any postembryonic divisions in male or female larval nervous systems.

      (Taylor and Truman, 1992)

      Dorsal musculature does not undergo sexual transformation.

      (Taylor, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Duncan.

      Comments
      Comments

      No sequence specific DNA binding activity by encoded product in gel mobility shift assays.

      (Erdman and Burtis, 1993)

      Rank order for subnormal courtship in dsx alleles is dsx1 < dsx16 < dsx15 < dsx23.

      (Villella and Hall, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dsx100.41
      (Erdman and Burtis, 1993)
      dsx15
      (Kimura et al., 2015)
      dsxD100.41
      Name Synonyms
      Secondary FlyBase IDs
        References (6)