FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eaD10
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General Information
Symbol
Dmel\eaD10
Species
D. melanogaster
Name
FlyBase ID
FBal0003483
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ea5022
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Amino acid replacement: P373S.

Nucleotide substitution: C1320T.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C15330299T

Reported nucleotide change:

C1320T

Amino acid change:

P373S | ea-PA; P242S | ea-PB

Reported amino acid change:

P373S

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos laid by heterozygous females are moderately ventralised; ventral denticle bands are expanded, dorsolaterally derived structures such as the filzkorper are reduced or absent and the dorsal hairs are almost completely missing. The embryos have head deformities. At gastrulation, embryos laid by mutant females invaginate an apparently normal ventral furrow, but initiation of the lateral cephalic furrow is shifted to a more dorsal position and fewer dorsal folds are formed than normal. Embryos laid by eaD10/Df(3R)ea-5022rx1 females are virtually indistinguishable from embryos laid by eaD10/+ females.

ea4/eaD10 larvae have a wild-type level of muscle defects.

Embryos moderately ventralized.

Female viability is reduced and male fertility is not reduced. Embryos exhibit ventralised phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0049450
References (9)