FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\elav19
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General Information
Symbol
Dmel\elav19
Species
D. melanogaster
Name
FlyBase ID
FBal0003648
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: G426E. Nucleotide substitution: G?A.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G517967A

Reported nucleotide change:

G?A

Amino acid change:

G426E | elav-PA; G422E | elav-PB; G422E | elav-PC; G426E | elav-PD

Reported amino acid change:

G426E

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

More severe than elav20. Flying/jumping ability and coordination are temperature-sensitive. ERG and optomotor responses are defective at 22oC and 29oC. Photoreceptor and optic lobe morphology are abnormal in flies raised at 29oC.

Affect retinula cell physiology. At 20oC electroretinograms (ERG) have a normal light coincident receptor potential (LCRP) but lack the on/ off transients. At 29oC the amplitude and rates of depolarization and repolarization of the light coincident receptor potential (LCRP) are noticeably reduced.

Abnormalities of visual system rearing at 29oC or high-temperature pulses delivered to pupae, raised otherwise at 20oC, causes vacuolization of photoreceptors and disorganization of rhabdomeres; high-temperature rearing or pupal pulsing induces severe optic lobe defects (absence of size reduction); electroretinograms of this mutant, raised at high-temperature, are missing light-on and light-off transient spikes (also seen after low-temperature rearing) and have reduction of ERG photoreceptor potential; amplitude of this potential also deteriorates as does deep pseudopupil when adults treated at high-temperature after low-temperature rearing.

Temperature-sensitive period for aberrant wing posture in elav19 extends from larval to pupal period.

temperature-sensitive

External Data
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Phenotypic Class
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Statement
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Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Homyk.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)