FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\en8
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General Information
Symbol
Dmel\en8
Species
D. melanogaster
Name
FlyBase ID
FBal0003723
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Also Known As
enLA10
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Tabata et al., 1995)
Mutagen
ethyl methanesulfonate
(Tabata et al., 1995, Kornberg, 1981)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Kornberg, 1981)
Description

Amino acid replacement: Q305term.

(Gustavson et al., 1996)

Amber mutant that terminates translation after residue 304. The encoded peptide lacks a homeodomain.

(Tabata et al., 1995)

Nonsense mutation at codon 305.

(Tabata et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,526,758..11,526,758 [-]
Nucleotide change:

C11526758T

Reported nucleotide change:

C?T

Amino acid change:

Q305term | en-PA; Q305term | en-PB

Reported amino acid change:

Q305term

(Whiteley and Kassis, 1997, Gustavson et al., 1996, Tabata et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Strong allele.

      (Gustavson et al., 1996)

      Clones in the wing reveal pattern abnormalities in the posterior compartment without extensive transformation to anterior and without polarity reversal or extensive ectopic growth as seen for clones of inv, en double mutant tissue.

      (Tabata et al., 1995)

      hh expression dependent on en function in stage 11 embryos.

      (Tabata et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      en8 has embryo phenotype, suppressible by Agam\eninv-12A

      (Whiteley and Kassis, 1997)

      en8 has embryo phenotype, suppressible by Agam\enen-12A-5R

      (Whiteley and Kassis, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Agam\eninv-12A rescues many aspects of the embryonic phenotype. Agam\enen-12A-5R rescue causes slight defects in the posterior compartments of the wings, both sexes are fertile.

      (Whiteley and Kassis, 1997)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Kornberg.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      en8
      enLA10
      (Whiteley and Kassis, 1997, Gustavson et al., 1996, Tabata et al., 1995, Tabata et al., 1992, Karr et al., 1985, Kornberg, 1981)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)