FlyBase Allele Report: Dmel\fs(1)Ya[5]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\fs(1)Ya⁵

General Information

Symbol

Dmel\fs(1)Ya⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0004493

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

fs(1)Ya⁷⁰, 13-1970

Key Links

Genomic Maps

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Liu et al., 1995, Mohler, 1977)

Progenitor genotype

Cytology

Description

Encoded product would be truncated by 41 amino acids at the C-terminus.

(Liu et al., 1995)

Nucleotide substitution: C2023T.

(Liu et al., 1995)

Amino acid replacement: Q655term.

(Liu et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

X:2,726,363..2,726,363 [+]

Nucleotide change:

C2726363T

Reported nucleotide change:

C2023T

Amino acid change:

Q655term | fs(1)Ya-PA

Reported amino acid change:

Q655term

(Liu et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

(Mohler, 1977)

(Liu et al., 1995)

Detailed Description

Statement

Reference

Females doubly mutant for gnu³⁰⁵ and fs(1)Ya⁵ or fs(1)Ya^14-77 exhibit gnu-like or fs(1)Ya-like nuclear morphology.

(Liu et al., 1997)

Mutant embryos arrest either with multiple abnormal nuclei or at the pronuclear stage, with fewer than four abnormally condensed nuclei, presumably derived from the sperm and female meiotic products. 69% of embryos are pronuclear arrested, 31% have multiple abnormal nuclei. Type II embryos of the multiple nuclear arrested class show fewer than 16 nuclei, which are not fragmented.

(Liu et al., 1995)

Weak allele. Most embryos from females homozygous for fs(1)Ya⁵ arrest at multinuclear stages rather than at the pronuclear fusion stage (in contrast to the strong fs(1)Ya² allele). More than 23% of these multinuclear embryos arrest as gastrulae.

(Lin and Wolfner, 1991)

Eggs are laid.

(Mohler and Carroll, 1984)

Homozygous females lay eggs that fail to hatch.

(Mohler, 1977)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

(Mohler, 1977)

Fails to complement

(Mohler, 1977)

(Mohler, 1977)

Rescued by

fs(1)Ya⁵ is rescued by fs(1)Ya^FAPKK.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^SY160.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^FEPKK.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^{N1.Hsp26.Tag:HA}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^C1.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^Hsp26.PL

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^ΔQ.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is rescued by fs(1)Ya^{ΔFSPKK.Hsp26}

(Liu and Wolfner, 1998)

Partially rescued by

fs(1)Ya⁵ is partially rescued by fs(1)Ya^C2.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{C2.SY160.Hsp26}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{N3.Hsp26.Tag:HA}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{ΔQ.ΔS:T.Hsp26}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{C3.Hsp26.Tag:HA}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{ΔITPIR.ΔFSPKK.Hsp26}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{IAPIR.FAPKK.Hsp26}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^IAPIR.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^ΔS:T.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is partially rescued by fs(1)Ya^{ΔITPIR.Hsp26}

(Liu and Wolfner, 1998)

Not rescued by

fs(1)Ya⁵ is not rescued by fs(1)Ya^C1.C2.Hsp26

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is not rescued by fs(1)Ya^{C2.FAPKK.Hsp26}

(Liu and Wolfner, 1998)

fs(1)Ya⁵ is not rescued by fs(1)Ya^{C1.C2.FAPKK.Hsp26}

(Liu and Wolfner, 1998)

Comments

fs(1)Ya⁵ is fully rescued by fs(1)Ya^Hsp26.PL, fs(1)Ya^{N1.Hsp26.T:Ivir\HA1}, fs(1)Ya^C1.Hsp26, fs(1)Ya^SY160.Hsp26, fs(1)Ya^ΔQ.Hsp26, fs(1)Ya^{ΔFSPKK.Hsp26}, fs(1)Ya^FAPKK.Hsp26 and fs(1)Ya^FEPKK.Hsp26 under both heat shock and non-heat shock conditions. fs(1)Ya⁵ is not rescued by fs(1)Ya^{C1.C2.FAPKK.Hsp26}, fs(1)Ya^{C2.FAPKK.Hsp26} or fs(1)Ya^4.28.1.1 under either heat shock and non-heat shock conditions. fs(1)Ya⁵ is partially rescued by fs(1)Ya^IAPIR.Hsp26, fs(1)Ya^{ΔITPIR.Hsp26} and fs(1)Ya^{IAPIR.FAPKK.Hsp26} under both heat shock and non-heat shock conditions. fs(1)Ya⁵ is slightly rescued by fs(1)Ya^C2.Hsp26, fs(1)Ya^{C2.SY160.Hsp26}, fs(1)Ya^{ΔQ.ΔS:T.Hsp26} and fs(1)Ya^{ΔITPIR.ΔFSPKK.Hsp26} under both heat shock and non-heat shock conditions. fs(1)Ya⁵ is not rescued under non-heat shock conditions, and very weakly rescued under heat shock conditions by fs(1)Ya^ΔS:T.Hsp26 and fs(1)Ya^{C3.Hsp26.T:Ivir\HA1}. fs(1)Ya⁵ is very weakly rescued under non-heat shock conditions, and partially rescued under heat shock conditions by fs(1)Ya^{N3.Hsp26.T:Ivir\HA1}.

(Liu and Wolfner, 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Mohler.

Comments

Comments

Partially complements fs(1)Ya^14-77 for female fertility: 15% of transheterozygotes develop to adulthood.

(Liu et al., 1995)

Leaky mutation.

(Liu et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

13-1970

(Mohler and Carroll, 1984, Mohler, 1977)

Ya⁷⁰

(Liu and Wolfner, 1998)

fs(1)M12^13-1970

fs(1)Ya⁵

fs(1)Ya⁷⁰

(Liu et al., 1997, Liu et al., 1995, Lin and Wolfner, 1991, Lin et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections