FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fs(3)Apc1
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General Information
Symbol
Dmel\Fs(3)Apc1
Species
D. melanogaster
Name
FlyBase ID
FBal0004733
Feature type
allele
Associated gene
Fs(3)Apc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Erdelyi and Szabad, 1989)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous females lay eggs that are abnormal in structure and lack dorsal appendages. Generation of wild type clones of follicle cells by X irradiation of females at the third instar phase rescues the mutant phenotype efficiently, up to 80% females lay normal eggs that undergo proper embryonic development.

      (Sapir et al., 1998)

      Female viability and male fertility are not reduced. Anterior egg coverings are incompletely formed leading to leakage of egg cytoplasm followed by degeneration of egg primordia and formation of flaccid eggs with rudimentry chorionic appendages.

      (Erdelyi and Szabad, 1989)

      dominant female-sterile. Majority of eggs produced by Fs(3)Apc/+ females collapse; 1-5% not flaccid. Respiratory appendages of chorion rudimentary as in the anterior chorion. When fertilized, resulting embryos rarely develop cuticular derivatives. Follicle cells in ovarioles fail to migrate between the oocyte and nurse cells. Mutant does not successfully revert. Germ-line chimaeras demonstrate that Fs(3)Apc is follicle-cell autonomous.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Females resulting from Atg1Δ3D/Fs(3)Apc irradiated larvae containing homozygous Atg1Δ3D follicle cell clones deposit non-typical Fs(3)Apc eggs that are non-flaccid, but contain short and rudimentary dorsal appendages. Embryonic cuticles do not appear in these eggs and no larvae hatch.

      (Barth et al., 2011)

      Female sterile phenotype cannot be rescued by germ line clones of rho or argos.

      (Sapir et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Fs(3)Apc
      (Barth et al., 2011)
      Fs(3)Apc10d
      (Erdelyi and Szabad, 1989)
      Fs(3)Apc1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)