FlyBase Allele Report: Dmel\ft[1]

General Information

Symbol

Dmel\ft¹

Species

D. melanogaster

Name

FlyBase ID

FBal0004787

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

Carried in Construct

Also Known As

fat¹

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Bryant et al., 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Yang et al., 2002)

short lived (with ft^G-rv)

(Fanto et al., 2003)

viable

(Yang et al., 2002, Zhimulev and Szidonya, 1991, Bryant et al., 1988)

visible | recessive

(Hogan et al., 2011, Mahoney et al., 1991, Bryant et al., 1988)

Phenotype Manifest In

adult abdomen

(Bryant et al., 1988)

adult thorax

(Bryant et al., 1988)

ommatidium

(Yang et al., 2002)

wing blade

(Hogan et al., 2011)

Detailed Description

Statement

Reference

ft¹ is a homozygous viable allele that affects wing shape, but not hair polarity. Ridges in distal regions of the posterior part of the mutant wings show an anterior-posterior orientation, in contrast to the normal proximal-distal orientation. Anterior ridges on the ft¹ mutant wings retain the normal anterior-posterior orientation.

(Hogan et al., 2011)

ft¹/ft^G-rv transheterozygotes are short lived as compared to controls.

(Fanto et al., 2003)

A small fraction ommatidia in homozygous mutant adults have a reversed dorsal ventral polarity.

(Yang et al., 2002)

Cause minor defects in adult morphology, Changes in body shape and wing vein pattern (Mohr, Studia Mendeliana, pp. 266--287). A viable mutation.

(Mahoney et al., 1991)

The adult abdomen and thorax is slightly shorter and wider than normal in homozygous flies. Transheterozygous ft¹/ft^G larvae have overgrown discs and generally die at the pupal stage, with some "exaggerated fat" escapers. ft¹ in transheterozygous combination with ft^G-rv or ft⁸ produces viable, "fat" flies.

(Bryant et al., 1988)

viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ft^G-rv/ft¹ has short lived phenotype, enhanceable by Gug¹¹/Gug[+]

(Fanto et al., 2003)

Other

Statement

Reference

ft¹, pk³⁰ has visible phenotype

(Hogan et al., 2011)

ft¹, pk³⁰ has abnormal planar polarity phenotype

(Hogan et al., 2011)

ft¹, lft^TG2 has abnormal planar polarity phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has visible phenotype

(Mao et al., 2009)

Gug³⁵, ft^G-rv/ft¹ has lethal | dominant phenotype

(Fanto et al., 2003)

Gug¹¹/Gug[+], ft^chance/ft¹ has short lived phenotype

(Fanto et al., 2003)

Gug³⁵, ft⁸/ft¹ has lethal | dominant phenotype

(Fanto et al., 2003)

Gug³⁵, ft^chance/ft¹ has lethal | dominant phenotype

(Fanto et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

ft¹ has crossvein phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

ft¹ has wing phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

NOT suppressed by

Statement

Reference

ft¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

ft¹/ft[+] is an enhancer of crossvein phenotype of fj^d1

(Strutt et al., 2004)

ft¹/ft[+] is an enhancer of wing phenotype of fj^d1

(Strutt et al., 2004)

ft¹/ft¹ is an enhancer of crossvein phenotype of fj^d1

(Strutt et al., 2004)

ft¹/ft¹ is an enhancer of wing phenotype of fj^d1

(Strutt et al., 2004)

Other

Statement

Reference

ft¹, pk³⁰ has wing hair phenotype

(Hogan et al., 2011)

ft¹, lft^TG2 has wing hair phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has wing vein | ectopic phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has leg phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has femur phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has posterior crossvein phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has tibia phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has tarsal segment phenotype

(Mao et al., 2009)

ft¹, lft^TG2 has wing vein L2 phenotype

(Mao et al., 2009)

Gug³⁵, ft^G-rv/ft¹ has eye phenotype

(Fanto et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

In comparison to a pk³⁰ homozygote, ft¹, pk³⁰ mutant wing hair polarity is more distal in both the anterior and in the distal posterior regions.

(Hogan et al., 2011)

The distance between the anterior and posterior crossveins is greatly reduced in ft¹ lft^TG2 double mutants. Additional phenotypes are seen in the double mutant that are not seen in either single mutant; the posterior crossvein is incomplete and the L2 vein is often both incomplete and associated with ectopic vein material.

ft¹ lft^TG2 double mutants have shorter legs than normal and individual leg segments (including the femur and tibia) are bother shorter and broader than normal (leg growth is only very subtly affected in either single mutant). The legs of the double mutant flies have only four tarsal segments instead of the usual five.

ft¹ lft^TG2 double mutants have obvious planar cell polarity phenotypes in the wings and legs (in contrast to either single mutant).

(Mao et al., 2009)

fj^d1; ft¹ double homozygotes have a much more severe wing shortening phenotype than either single mutant. The distance between anterior and posterior crossveins in the wings of these flies is reduced to almost zero. The wing shortening phenotype of fj^d1 homozygotes is also enhanced by ft¹/+.

(Strutt et al., 2004)

The short lived phenotype of ft¹/ft^G-rv transheterozygotes is enhanced by Gug¹¹ heterozygosity. ft¹/ft^chance, Gug¹¹/+ adults are also short lived.

(Fanto et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (5)