FB2026_02 , released June 18, 2026
Allele: Dmel\ftz5
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General Information
Symbol
Dmel\ftz5
Species
D. melanogaster
Name
FlyBase ID
FBal0004810
Feature type
allele
Associated gene
Dmel\ftz
Associated Insertion(s)
Carried in Construct
Also Known As
ftzf47ts
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Weiner et al., 1984)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: A291V.

(Fitzpatrick and Ingles, 1989)

Nucleotide substitution: C1022T.

(Laughon and Scott, 1984)

Amino acid replacement: A?V.

(Laughon and Scott, 1984)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,865,403..6,865,403 [+]
Nucleotide change:

C6865403T

Amino acid change:

A288V | ftz-PA

(Laughon and Scott, 1984)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 26.5oC, about 64% of ftz5/ftz13 animals survive to adulthood, while at 27.5oC, about 35% survive to adulthood. At 26.5oC, ftz5/ftz13 embryos show variable segmentation phenotypes, ranging from normal to having defects in three ftz-dependent denticle belts. At 27.5oC, 53.8% of ftz5/ftz13 embryos have segment defects, with 4.3% having 3 ftz-dependent segments affected.

      (Kankel et al., 2004)

      Temperature sensitive mutation.

      (Fitzpatrick and Ingles, 1989)

      ftz5/Df(3R)Scr embryos grown at the non-permissive temperature show a variable phenotype. The germ band shows alternating bands of marked boundaries and more superficial indentations, which results in a mixture of normal and double-width segments. Viability is reduced at the permissive temperature.

      (Wakimoto et al., 1984)

      Hemizygous embryos have partial gaps and/or fusions in some denticle belts while others appear normal. This phenotype is similar to that of ftzRpl.

      (Weiner et al., 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4236[+]/E(ftz)42364236

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)18151815/E(ftz)1815[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)18191819/E(ftz)1819[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)2020/E(ftz)20[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)2142[+]/E(ftz)21422142

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)28282828/E(ftz)2828[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)29552955/E(ftz)2955[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable by E(ftz)723[+]/E(ftz)723723

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)3150[+]/E(ftz)31503150

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)32013201/E(ftz)3201[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4038[+]/E(ftz)40384038

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)4758[+]/E(ftz)47584758

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)53035303/E(ftz)5303[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug[+]/Gug1757

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug2295/Gug[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug3333/Gug[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by bek1/bek[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f1[+]/ftz-f13443

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f1[+]/ftz-f15308

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by Gug519/Gug[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by hth2232/hth[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by ftz-f12478/ftz-f1[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable by eIF4E12188/eIF4E1[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable by how[+]/how2455

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)10271027/E(ftz)1027[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has partially lethal | heat sensitive phenotype, enhanceable | maternal effect by E(ftz)1427[+]/E(ftz)14271427

      (Kankel et al., 2004)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)723[+]/E(ftz)723723

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)18191819/E(ftz)1819[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)2020/E(ftz)20[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)2142[+]/E(ftz)21422142

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)29552955/E(ftz)2955[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)3150[+]/E(ftz)31503150

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)32013201/E(ftz)3201[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)4038[+]/E(ftz)40384038

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by Gug[+]/Gug1757

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by Gug519/Gug[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by Gug3333/Gug[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by bek1/bek[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by ftz-f1[+]/ftz-f13443

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by ftz-f1[+]/ftz-f15308

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by hth2232/hth[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by ftz-f12478/ftz-f1[+]

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)1427[+]/E(ftz)14271427

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, enhanceable by E(ftz)18151815/E(ftz)1815[+]

      (Kankel et al., 2004)
      Suppressed by
      Statement
      Reference

      ftz5/ftz13 has embryonic segment phenotype, suppressible by E(ftz)4236[+]/E(ftz)42364236

      (Kankel et al., 2004)

      ftz5/ftz13 has embryonic segment phenotype, suppressible by how[+]/how2455

      (Kankel et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The segmentation defects seen in ftz5/ftz13 embryos at 27.5oC are dominantly enhanced by the following (in each case the % of embryos with segmentation defects followed by the % of embryos with at least 3 ftz-dependent segments affected are given in parentheses after the enhancing allele); ftz-f12478 (95.9%, 44.7%), ftz-f13443 (98.5%, 35.1%), ftz-f15308 (91.3%, 40.5%), Gug519 (100%, 90.2%), Gug1757 (89.7%, 55.1%), Gug3333 (98.7%, 98.0%), bek1 (92.5%, 61.9%), hth2232 (73.9%, 16.3%), E(ftz)2020 (72.4%, 11.2%), E(ftz)723723 (91.9%, 32.5%), E(ftz)14271427 (99.4%, 93.1%), E(ftz)18151815 (72.1%, 22.1%), E(ftz)18191819 (97.8%, 31.3%), E(ftz)21422142 (93.1%, 13.2%), E(ftz)29552955 (78.5%, 16.2%), E(ftz)31503150 (95.0%, 79.4%), E(ftz)32013201 (88.7%, 15.5%), E(ftz)40384038 (82.9%, 23.6%). how2455 dominantly suppresses the segmentation defects seen in ftz5/ftz13 embryos at 27.5oC; 26.2% of the embryos have segment defects and 1.5% have at least 3 ftz-dependent segments affected. E(ftz)42364236 dominantly suppresses the segmentation defects seen in ftz5/ftz13 embryos at 27.5oC; 39.0% of the embryos have segment defects and 1.2% have at least 3 ftz-dependent segments affected.

      (Kankel et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Fornili.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      f47ts
      (Wakimoto et al., 1984)
      ftz5
      ftzf47
      (Wakimoto et al., 1984)
      ftzf47ts
      (Kankel et al., 2004, Kankel and Duncan, 1997, Fitzpatrick and Ingles, 1989, Laughon et al., 1988, Weiner et al., 1984)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)