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General Information
Symbol
Dmel\ftzUal3
Species
D. melanogaster
Name
FlyBase ID
FBal0004825
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C6865027T

Amino acid change:

P212S | ftz-PA

Reported amino acid change:

P215S

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: C?T. Amino acid replacement: P215S. Numbering derived from FBrf0041541.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A subset of adults that survive from embryos heat shocked for 15 minutes during cellularisation at 37oC exhibit homeotic transformations of portions of the abdominal segment 1 to segment 3 identity. A variety of segmentation defects also occur. Presence of Kr2 increases the frequency of abdominal segment 1 transformations.

Variable transformation of A1 to A3. The posterior compartment of A1 and a zone at the anterior margin of A1 are rarely affected. In those cases where they are affected, it is not clear whether they are transformed or deleted. At a low frequency, the following transformations are seen: posterior haltere (T3 structure) to posterior wing (T2 structure), A3 to A5, and A4 to A5. No segmental transformations seen in the embryo. Segmental defects are seen in the abdominal cuticle of adult heterozygotes, with a preference for malformations in even-numbered segments. Defects are most frequent in A4. Defect frequencies are higher in homozygotes of ftzUal2 and heteroallelic combinations of ftzUal1, ftzUal2 and ftzUal3. Defects are also frequently seen in the posterior region of T2 and the anterior region of T3 in adults. Segmental defects are also seen in embryos, with the highest defect frequency in T1, T3, A4, A6 and A8. The A1 transformation phenotype is affected by mutations of Kr, Pc and hb.

dominant

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Duncan.

Comments
Comments

Wild type embryos under the same heat shock regime exhibit the same homeotic transformations, a phenocopy.

External Crossreferences and Linkouts ( 2 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ftzUal3
Name Synonyms
Ultra-abdominal-like
Secondary FlyBase IDs
    References (3)