FlyBase Allele Report: Dmel\fu[14]

General Information

Symbol

Dmel\fu¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0004847

Feature type

allele

Associated gene

Dmel\fu

Associated Insertion(s)

Carried in Construct

Also Known As

fu⁶²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

gamma ray

(Therond et al., 1996, Busson et al., 1988)

X ray

(Preat et al., 1993)

Progenitor genotype

Cytology

Description

Point mutation within the kinase domain.

(Robbins et al., 1997)

9bp deletion of genomic sequences 1389-1397, amino acids 139-141 that lie adjacent to the DFG triplet.

(Therond et al., 1996)

9-bp deletion.

(Preat, 1994.9.22)

9bp deletion in the kinase domain. Class I fu allele, affects the catalytic domain but does not change the open reading frame.

(Preat et al., 1993)

8bp deletion within putative kinase domain.

(Preat et al., 1990)

Deletion of approximately 8bp.

(Preat, 1990)

9bp deletion

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:18,658,325..18,658,333 [+]

Comment:

9bp deletion

(Preat et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-fertile

lethal

(Busson et al., 1988)

viable

(Busson et al., 1988)

visible

(Ascano et al., 2002, Busson et al., 1988)

Phenotype Manifest In

double row of wing sensilla | ectopic

(Ascano et al., 2002)

first posterior wing cell

(Ascano et al., 2002)

wing vein

wing vein L3

(Busson et al., 1988)

wing vein L4

(Busson et al., 1988)

Detailed Description

Statement

Reference

Mutants show proximal fusions between wing veins L3 and L4, as well as a narrowing of the distance between these veins distally. At the wing margin, double row bristles extend beyond vein 3 to vein 4.

(Ascano et al., 2002)

Weak wing phenotype - veins L3 and L4 fused only proximally. Weak fecundity phenotype - ratio of eggs laid by fu/fu versus fu/+ sisters is 0.5-1.0.

(Busson et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

fu¹⁴ has phenotype, suppressible by Su(fu)^LP

(Preat et al., 1993)

Suppressor of

Statement

Reference

fu¹⁴ is a suppressor of wing vein phenotype of Scer\GAL4^unspecified, hh^N.UAS

(Ramirez-Weber et al., 2001)

fu¹⁴ is a suppressor of wing | anterior phenotype of Scer\GAL4^unspecified, hh^N.UAS

(Ramirez-Weber et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

When in combination with Su(fu)^LP heterozygotes individuals display a partially suppressed fu phenotype.

(Preat et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Fahmy, 3rd June 1962.

Comments

Class I mutation based on interaction with Su(fu)^LP, suppression of embryonic and adult phenotype.

(Therond et al., 1996)

Class I allele.

(Robbins et al., 1997)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S69165

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB29840

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

fu¹⁴

fu¹

(Ramirez-Weber et al., 2001)

fu⁶²

(Ascano et al., 2002, Ramirez-Weber et al., 2001, Dominguez, 1999, Robbins et al., 1997, Therond et al., 1996, Preat et al., 1993, Preat, 1990, Preat et al., 1990, Busson et al., 1988)

fu^62f3

(Ma et al., 1996)

Name Synonyms

Secondary FlyBase IDs

FBal0028199

References (14)

Report Sections

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