FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fwdneo1
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General Information
Symbol
Dmel\fwdneo1
Species
D. melanogaster
Name
FlyBase ID
FBal0004914
Feature type
allele
Associated gene
Dmel\fwd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Berg and Spradling, 1991)
Progenitor genotype
Cytology
Description

Complex rearrangement.

(Brill et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      spermatid & nucleus (with Df(3L)7C)

      (Brill et al., 2000)
      Detailed Description
      Statement
      Reference

      fwdneo1/Df(3L)7C adults show decreased climbing activity.

      (Terriente-Felix et al., 2020)

      99.8% of spermatids in the testes of fwdneo1/Df(3L)7C males are defective, being derived from one or more defective meiotic and/or mitotic divisions. Spermatids with 4 nuclei per mitochondrial derivative are often seen, and spermatids with 2 or 8 nuclei per mitochondrial derivative are also sometimes seen.

      (Brill et al., 2000)

      Failure of cytokinesis after meiosis I and meiosis II in males, usually resulting in onion stage early spermatids with four equal sized nuclei associated with a single, large mitochondrial derivative. Cells in meiosis II contain two spindles. female-fertile

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Sprading, 1988.

      C. Berg and A. Spradling.

      (Berg and Spradling, 1991)

      Separable from: P{hsneo}AS69. The insertion in the line (P{hsneo}AS69) is separable from the fwdneo1 lesion.

      (Brill et al., 2000)

      Separable from: P{hsneo}AS69. Separable from: l(3)AS691.

      (Matthews, 2006.1.25)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      fwd1
      (Brill et al., 2000, Brill et al., 1999)
      fwdNeo1
      (Bothe et al., 2014)
      fwdneo1
      (Terriente-Felix et al., 2020, Weber et al., 2012, Anderson et al., 2009)
      ms(3)neo1
      neo 1
      (Berg and Spradling, 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)