FlyBase Allele Report: Dmel\Gpdh1[B]

General Information

Symbol

Dmel\Gpdh1^B

Species

D. melanogaster

Name

FlyBase ID

FBal0005136

Feature type

allele

Associated gene

Dmel\Gpdh1

Associated Insertion(s)

Carried in Construct

Also Known As

Gpdh^S, S, αGpdh^S, α-Gpdh^S

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

natural population

Nature of the Allele

Allele class

Mutagen

natural population

(Parkash et al., 1993, Bewley et al., 1989)

Progenitor genotype

Cytology

Description

Position of mutation is relative to Gpdh^A.

(Kusakabe et al., 1990)

Amino acid replacement: N?K.

(Kusakabe et al., 1990)

Nucleotide substitution: T3338A.

(Kusakabe et al., 1990)

Amino acid replacement: N336K.

(Bewley et al., 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

sequence_variant

2L:5,947,294..5,947,294 [+]

Nucleotide change:

T9166A

Amino acid change:

Comment:

Amino acid change thought to confer the electrophoretic mobility difference between the Fast and Slow allozymes. The reference sequence contains the Fast allele.

(Bewley et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

electrophoretic variant

(Bubli et al., 1996, Parkash and Shamina, 1994, Parkash et al., 1993, Bewley et al., 1984)

Phenotype Manifest In

Detailed Description

Statement

Reference

Genotypes reared at 25^oC died at 35^oC. Flies reared at 29^oC showed less significant differences in survival between genotypes than flies reared at 20^oC and 25^oC. Protein content, triglyceride content and ADH enzyme activity decreased significantly at 35^oC, no correlation was observed between survival and these traits.

(Oudman et al., 1992)

Egg to adult developmental time of Gpdh genotypes depends on the Adh genotype and temperature. Homoygotes have the slowest developmental time of all Gpdh genotypes, Gpdh^A/Gpdh^B heterozygotes have an intermediate development rate between the homozygotes. Adult weight of Gpdh genotypes interacts with temperature but not with Adh genotype. The Gpdh heterozygote has a significantly higher triglyceride content than the homozygotes which have a similar lower content, the values varied slightly in different Adh genotypes and temperatures. The differences in GPDH activity for all the Gpdh genotypes was small at all temperatures and Adh genotypes.

(Oudman et al., 1991)

electrophoretic variant: Slow

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (6)

Bloomington

2369

SM1, Got2¹ Gpdh1^A Mdh1⁴ Adh^F Cndp2⁴ Hex-C⁴ Amy-d¹/Got2² Gpdh1^B Mdh1⁶ Adh^S Cndp2² Hex-C⁶ Amy-p² Amy-d³

Kyoto

101493

Gpdh1^B / SM1, Gpdh1^nR1

103253

cl¹ Gpdh1^B wg^spd-fg

101983

Gpdh1^B Mdh1^S Adh^F ; Fdh^F Aldox89A^S

101984

Gpdh1^B Mdh1^S Adh^S ; Fdh^S Aldox89A^S

107289

SM1, Got2¹ Gpdh1^A Mdh1⁴ Adh^F Cndp2⁴ Hex-C⁴ Amy-d¹; Got2² Gpdh1^B Mdh1⁶ Adh^S Cndp2² Hex-C⁶ Amy-p² Amy-d³

Notes on Origin

Discoverer

Comments

Homodimeric Gpdh enzyme encoded by Gpdh^B and heterodimeric Gpdh enzyme encoded by Gpdh^B and Gpdh^UF has been purified and characterised.

(Bewley et al., 1984)

The frequency of the Gpdh^B allele in Eurasian natural populations increases in the Western part of Eurasia and is not associated with climatic variables.

(Bublii et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

GPDH^S

(Bewley et al., 1989)

Gpdh1^B

Gpdh⁴

Gpdh^B

Gpdh^S

(Bubliy et al., 1999, Bartoszewski and Gibson, 1998, Kang et al., 1998, Koga et al., 1993, Symonds and Gibson, 1992, Geer et al., 1991, Gibson et al., 1991, Kusakabe et al., 1990, Takano et al., 1989, Bewley et al., 1984, Bewley, 1983, Niesel et al., 1982, Bewley, 1981)

(Ochando and Ayala, 1999, Bubli et al., 1996, el Abidin Salam et al., 1993, Kamping and van Delden, 1991)

α-GPDH-S

(Bublii et al., 1994)

α-Gpdh⁴

(Racine et al., 1980)

α-Gpdh^S

(Parkash and Shamina, 1994, Parkash and Vandna, 1994, Alahiotis, 1974)

αGpdh^S

(Kamping and Van Delden, 1999, Santos et al., 1999, Oudman et al., 1994)

Name Synonyms

Gpdh-Slow

(Sezgin et al., 2004)

Secondary FlyBase IDs

FBal0038844

References (35)

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