FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grk4
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General Information
Symbol
Dmel\grk4
Species
D. melanogaster
Name
FlyBase ID
FBal0005212
Feature type
allele
Associated gene
Dmel\grk
Associated Insertion(s)
roo{}grk4
Carried in Construct
Also Known As
grkHL, grkHL23
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Neuman-Silberberg and Schupbach, 1996, Neuman-Silberberg and Schupbach, 1993, Schupbach and Wieschaus, 1991, Schupbach, 1987)
Progenitor genotype
Associated Insertion(s)
roo{}grk4
Cytology
Description

A 432bp insertion homologous to a fragment of the roo element is inserted at bp2336.

(Thio et al., 2000)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Reduction or absence of dorsal appendages (ventralization) with increase in main body egg shell. Micropyle at both ends of eggs, embryos ventralized.

      (Schupbach and Wieschaus, 1991)

      An enlarged mass of mesodermal cells invaginates on the ventral side of the embryo, the enlarged mesoderm is often organised into two ventral furrows. Organisation is lost in later stages of development and a mass of mesodermal cells fills the ventral half of the embryo. Respiratory appendages are completely absent and only the ventral most portion of the operculum is present.

      (Schupbach, 1987)

      phenotype of eggs and embryos: intermediate and strong

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong grk allele.

      (Schupbach, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (5)