FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grk5
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General Information
Symbol
Dmel\grk5
Species
D. melanogaster
Name
FlyBase ID
FBal0005213
Feature type
allele
Associated gene
Dmel\grk
Associated Insertion(s)
Carried in Construct
Also Known As
grkQI, grkQI66
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Neuman-Silberberg and Schupbach, 1996, Neuman-Silberberg and Schupbach, 1993, Schupbach and Wieschaus, 1991, Schupbach, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: A245T. Nucleotide substitution: G2423A.

(Thio et al., 2000)

Amino acid replacement: A245T.

(Queenan et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,431,694..8,431,694 [-]
Nucleotide change:

G8431694A

Reported nucleotide change:

G2423A

Amino acid change:

A246T | grk-PA

Reported amino acid change:

A245T

(Thio et al., 2000, Queenan et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Reduction or absence of dorsal appendages (ventralization) with increase in main body egg shell. Micropyle at both ends of eggs, embryos ventralized.

      (Schupbach and Wieschaus, 1991)

      An enlarged mass of mesodermal cells invaginates on the ventral side of the embryo, the enlarged mesoderm is often organised into two ventral furrows. Organisation is lost in later stages of development and a mass of mesodermal cells fills the ventral half of the embryo. Respiratory appendages are fused and shortened and adjacent operculum is reduced.

      (Schupbach, 1987)

      phenotype of eggs and embryos: mostly intermediate, but can vary from weak to strong

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Intermediate grk allele.

      (Schupbach, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      grk5
      grkQI66
      (Thio et al., 2000, Queenan et al., 1999)
      grkQI
      (Neuman-Silberberg and Schupbach, 1996, Neuman-Silberberg and Schupbach, 1993, Schupbach, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)