FlyBase Allele Report: Dmel\gsb[01155]

(Losada-Pérez et al., 2013, Marie et al., 2010, De Graeve et al., 2004, Spradling et al., 1999, Duman-Scheel et al., 1997, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Perrimon et al., 1996)

some die during embryonic stage | recessive

(Perrimon et al., 1996)

Phenotype Manifest In

cuticle

(Perrimon et al., 1996)

larval DA2 motor neuron

(Duman-Scheel et al., 1997)

larval DO1 motor neuron

(Duman-Scheel et al., 1997)

larval DO2 motor neuron

(Duman-Scheel et al., 1997)

larval posterior commissure

(Duman-Scheel et al., 1997)

larval RP2 motor neuron

(Duman-Scheel et al., 1997)

U neuron

(Duman-Scheel et al., 1997)

ventral denticle belt

(Perrimon et al., 1996)

Detailed Description

Statement

Reference

Motoneurons in gsb⁰¹¹⁵⁵/+ heterozygotes navigate into the periphery and establish the correct stereotyped pattern of synaptic connections with particular muscle cells.

Synaptic transmission is normal in gsb⁰¹¹⁵⁵/+ heterozygotes.

(Marie et al., 2010)

Mutants exhibit occasional duplication of RP2 neurons and frequent loss of U and CQ neurons. Posterior commissures are missing or reduced.

(Duman-Scheel et al., 1997)

Germline clones produce eggs with patterning defects: mirror image duplication of denticle belts.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

GluRIIA^SP16, gsb[+]/gsb⁰¹¹⁵⁵ has abnormal neurophysiology phenotype, suppressible by wg^l-12/wg[+]

(Marie et al., 2010)

Suppressor of

Statement

Reference

gsb[+]/gsb⁰¹¹⁵⁵ is a suppressor of abnormal neurophysiology phenotype of GluRIIA^SP16, wg^l-12/wg[+]

(Marie et al., 2010)

gsb[+]/gsb⁰¹¹⁵⁵ is a suppressor of abnormal neurophysiology phenotype of GluRIIA^SP16

(Marie et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

GluRIIA^SP16, gsb[+]/gsb⁰¹¹⁵⁵ has neuromuscular junction phenotype, suppressible by wg^l-12/wg[+]

(Marie et al., 2010)

Suppressor of

Statement

Reference

gsb[+]/gsb⁰¹¹⁵⁵ is a suppressor of neuromuscular junction phenotype of GluRIIA^SP16, wg^l-12/wg[+]

(Marie et al., 2010)

gsb[+]/gsb⁰¹¹⁵⁵ is a suppressor of neuromuscular junction phenotype of GluRIIA^SP16

(Marie et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A gsb⁰¹¹⁵⁵/+ heterozygous background significantly suppresses the magnitude of synaptic homeostasis that is expressed in a GluRIIA^SP16 mutant background.

There is significantly more homeostatic compensation found in wg^l-12/+ GluRIIA^SP16 ; gsb⁰¹¹⁵⁵ compared to wg^l-12/+ GluRIIA^SP16 mutants. The presence of wg^l-12/+ restores homeostatic compensation to levels that are statistically the same as those observed in GluRIIA^SP16 single mutants.

(Marie et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

gsb⁰¹¹⁵⁵ is rescued by gsb^+t20.1

(Duman-Scheel et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10999

cn¹ P{PZ}gsb⁰¹¹⁵⁵/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Separable from: Eip75B⁰¹¹⁵⁵. Evidence suggests that the "l(2)01155" line contains 2 P{PZ} insertions; one at 75B (P{PZ}Eip75B⁰¹¹⁵⁵) corresponding to the site of the flanking sequence AQ073261, and one at 60F (P{PZ}gsb⁰¹¹⁵⁵) which causes a mutation in gsb.

(FlyBase, 1996-)

Comments

Complements: l(2)00064⁰⁰⁰⁶⁴. Complements: Kr⁰⁰⁸⁹⁵. Complements: Dll⁰¹⁰⁹². Complements: l(2)01848⁰¹⁸⁴⁸. Complements: l(2)10481⁰³²⁶³. Complements: l(2)10481¹⁰⁴⁸¹. Complements: Kr^k05826. Complements: mts^k12502. Complements: zip^k15609.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

gsb-d⁰¹¹⁵⁵

(Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

gsb-d^P1155

(Duman-Scheel et al., 1997)

gsb⁰¹¹⁵⁵

(Losada-Pérez et al., 2013, Marie et al., 2010)

gsb^P1155

(He and Noll, 2013)

l(2)01155

(Spradling et al., 1999)

l(2)01155⁰¹¹⁵⁵

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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