her1/her2 females develop as sterile intersexes at 25oC or 29oC and are normal and fertile at 18oC. Daughters of her1/her2 mothers are severely affected by the presence of a sisA point mutation and Sxlf9, viability can be restored by the presence of SxlM1. The presence of SxlfLS does not affect the daughters.
Homozygous females are transformed to intersexes under restrictive and semi-restrictive temperatures (29oC and 25oC). Mutant males show a weak transformation to intersexuality in the sixth sternite has bristles. Surviving daughters of homozygotes and transheterozygotes raised at semi-restrictive temperatures show a high frequency of morphological defects not seen in sons. Maternal effect female lethality is enhanced by Sxlf1. Severely restrictive conditions (29oC for more than 2 days) reveals maternal sex-nonspecific lethality for all heteroallelic combinations except her3/her2 : embryos show defect in gastrulation and differentiation of the cuticles.
Arose on: In(2LR)SM1.
Relative severity of the effects on female and male sexual differentiation is her3 > her1 > her2 > hermat-1. Relative severity of the effects on viability is her3 > her1 = her2 > hermat-1.