FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hnr3
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General Information
Symbol
Dmel\Hnr3
Species
D. melanogaster
Name
recessive-3
FlyBase ID
FBal0005505
Feature type
allele
Associated gene
Dmel\Hn
Associated Insertion(s)
roo{}Hnr3
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Associated Insertion(s)
roo{}Hnr3
Cytology
Description

roo element insertion (of at least 7.2kb) in exon 3. The roo element is inserted in the opposite orientation with respect to the Hn gene. A 24bp deletion has also occurred in intron 1.

(Ruiz-Vazquez and Silva, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:7,761,481..7,761,504 [+]
Comment:

A 24 base deletion maps to an intron. The Hnr3 allele also contains the ~7.2kb roo{}Hnr3 insertion.

(Ruiz-Vazquez and Silva, 1999)
transposable_element_insertion_site
3L:7,762,477..7,762,480 [+]
(Ruiz-Vazquez and Silva, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ001717
AJ001718
CAA04950
AJ001720
AJ001721
AJ001722
CAB51599
AJ001723
CAB51597
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hnbp/Hnr3 flies have purple eyes.

      (Wang et al., 2008)

      Has 10% of wild type levels of phenylalanine hydroxylase enzyme activity and correspondingly reduced CRM.

      (Silva et al., 1992)

      Homozygotes of Hnr3 and ry6 viable. Eye colour: dull chocolate; classification easier than for Hnr.

      (Thompson, 1983)

      Seventy-nine percent normal red pigment, 100% normal brown pigment.

      (Nolte, 1955)

      Eye color autonomous in transplants of optic disk into wild-type hosts.

      (Beadle and Ephrussi, 1936)

      More extreme than Hnr2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (2)
      Stocks (3)
      Notes on Origin
      Discoverer

      Weinstein, 1927.

      Comments
      Comments

      Completely lacks 5,6,7,8-tetrahydroperin and increased levels of 5,6,7,8-tetrahydrobioperin.

      (Guillamon and Ferre, 1988)

      No detectable levels of Hn protein.

      (Alcaniz and Silva, 1997)
      External Crossreferences and Linkouts ( 10 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hnr3
      (Wang et al., 2008)
      sed
      Name Synonyms
      recessive-3
      (Guillamon and Ferre, 1988)
      sepiaoid
      Secondary FlyBase IDs
        References (12)