FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kni11
Open Close
General Information
Symbol
Dmel\kni11
Species
D. melanogaster
Name
FlyBase ID
FBal0005781
Feature type
allele
Associated gene
Dmel\kni
Associated Insertion(s)
Carried in Construct
Also Known As
kniIIE72
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gerwin et al., 1994, Eldon and Pirrotta, 1991)
Mutagen
ethyl methanesulfonate
(Gerwin et al., 1994, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T2934A. Amino acid replacement: C48S.

(Gerwin et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:20,693,984..20,693,984 [-]
Nucleotide change:

T20693984A

Reported nucleotide change:

T2934A

Amino acid change:

C48S | kni-PA; C53S | kni-PB

Reported amino acid change:

C48S

(Gerwin et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Slight effect on gt stripe 4 domain: posterior border is less well defined and the anterior border fades rapidly at the end of cellular blastoderm.

      (Eldon and Pirrotta, 1991)

      Larval phenotype: abdominal segments A1-A7 fused, dominant defects in A2-A5.

      (Carroll and Scott, 1986)

      strong

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reduced maternal RpL36 activity increases the penetrance and severity of the segmental defects observed in larvae heterozygous for Kr or kni mutations.

      (Duffy et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (11)