FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tfb106949
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General Information
Symbol
Dmel\Tfb106949
Species
D. melanogaster
Name
FlyBase ID
FBal0008121
Feature type
allele
Associated gene
Dmel\Tfb1
Associated Insertion(s)
P{PZ}Tfb106949
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}Tfb106949
Cytology
Description

P{PZ} insertion at the 5' end of the first exon of Tfb1, just upstream of the ATG initiation codon.

(Castro et al., 2002)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous larvae are more sensitive to UV irradiation than wild-type controls. When irradiated at 136J/m2, no heterozygous larvae develop to adults, whereas 30% of controls survive. Heterozygotes that do survive UV irradiation show severe cuticular damage, even in the presence of low UV irradiation doses.

      (Castro et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: l(2)0057200572. Complements: ttv00681b. Complements: L02637. Complements: l(2)0356303563. Complements: Sec61β07214. Complements: l(2)k16805k16805.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dmp62mut
      (Castro et al., 2002)
      Tfb106949
      (Bischoff et al., 2009)
      l(2)06949
      (Misra, 2000.11.18, Spradling et al., 1999)
      l(2)0694906949
      (Dickson et al., 1995, BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)