FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Col4a1DTS-L4
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General Information
Symbol
Dmel\Col4a1DTS-L4
Species
D. melanogaster
Name
FlyBase ID
FBal0008287
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DTS-L4
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: G1025E.

Nucleotide substitution: G?A.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G5034121A

Reported nucleotide change:

G?A

Amino acid change:

G1025E | Col4a1-PA; G1025E | Col4a1-PB; G1025E | Col4a1-PC

Reported amino acid change:

G1025E

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The oviduct muscle of Col4a1DTS-L4 homoygotes loses the typical sarcomeric structure at the restrictive temperature of 29[o]C, but not at the permissive temperature of 20[o]C; there are areas of actin bundling that extend beyond the area of a regular sarcomere; the Z-disc structure is disrupted; muscle fiber diameters decrease and become more heterogeneous.

The common oviduct muscle of Col4a1a-30/Col4a1DTS-L4 transheterozygotes also show loss of the sarcomeric structure and actin bundling at the restrictive temperature.

Cg25CDTS-L4 heterozygotes show dominant semi-lethality at 29[o]C but are viable at 20[o]C. Homozygotes raised at 20[o]C are lethal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Cg25CDTS-L4
Col4a1DTS-L4
col4a1G1025E1
l(2)25Ca3
Name Synonyms
Secondary FlyBase IDs
    References (3)