Amino acid replacement: G1025E.
Nucleotide substitution: G?A.
G5034121A
G?A
G1025E | Col4a1-PA; G1025E | Col4a1-PB; G1025E | Col4a1-PC
G1025E
sarcomere | adult stage | heat sensitive (with Col4a1a-30)
The oviduct muscle of Col4a1DTS-L4 homoygotes loses the typical sarcomeric structure at the restrictive temperature of 29[o]C, but not at the permissive temperature of 20[o]C; there are areas of actin bundling that extend beyond the area of a regular sarcomere; the Z-disc structure is disrupted; muscle fiber diameters decrease and become more heterogeneous.
The common oviduct muscle of Col4a1a-30/Col4a1DTS-L4 transheterozygotes also show loss of the sarcomeric structure and actin bundling at the restrictive temperature.
Cg25CDTS-L4 heterozygotes show dominant semi-lethality at 29[o]C but are viable at 20[o]C. Homozygotes raised at 20[o]C are lethal.
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgsz-14
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgsz-6
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgk16721
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkghsneo80
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgsz-78
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgb-35
Col4a1DTS-L4 has lethal | recessive phenotype, suppressible by vkgb-14
Col4a1DTS-L4 is a suppressor | partially of lethal | recessive phenotype of vkghsneo80
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgk16721
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgsz-6
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgb-14
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgb-35
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgsz-14
Col4a1DTS-L4 is a suppressor of lethal | recessive phenotype of vkgsz-78