FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nipped-A1
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General Information
Symbol
Dmel\Nipped-A1
Species
D. melanogaster
Name
FlyBase ID
FBal0009007
Feature type
allele
Associated gene
Dmel\Nipped-A
Associated Insertion(s)
Carried in Construct
Also Known As
EMS34-4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hilliker, 1976)
Progenitor genotype
Cytology
Description

Point mutation.

(Hilliker, 1976)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      8% of Nipped-A1/Nipped-A8 heterozygotes are viable.

      (Hilliker, 1976)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nipped-A1 is an enhancer of phenotype of run3

      (Duffy et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mutant chromosome acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 40% of run3 heterozygotes. Heterozygous run embryos derived from heterozygous l(2)41Ae34-4, Nipped-A1/+ females show run-associated abdominal segmentation defects. Similar effects are seen with heterozygotes for Kr and eve mutations. Maternal heterozygosity for l(2)41Ae34-4, Nipped-A1 has no effect on the viability of Kr heterozygotes.

      (Duffy et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Chromosome carrying Nipped-A1 is a double mutant chromosome, and also carries l(2)41Ae34-4.

      (Duffy et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EMS34-4
      (Duffy et al., 1996, Hilliker, 1976)
      Nipped-A1
      l(2)41Ah1
      l(2)EMS34-04
      Name Synonyms
      Secondary FlyBase IDs
        References (2)