FlyBase Allele Report: Dmel\pnt[07825]

General Information

Symbol

Dmel\pnt⁰⁷⁸²⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0009603

Feature type

allele

Associated gene

Dmel\pnt

Associated Insertion(s)

P{PZ}pnt⁰⁷⁸²⁵

Carried in Construct

Also Known As

pnt-lacZ, pnt⁷⁸²⁵, l(3)07825

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(O'Neill et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{PZ}pnt⁰⁷⁸²⁵

Cytology

Description

P element insert maps close to P2 product exon IV.

(O'Neill et al., 1994)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:23,314,467..23,314,467 [+]

(Verma et al., 2012, Alvarez et al., 2003, Sudarsan et al., 2002, Spradling et al., 1999, Maixner et al., 1998, Forjanic et al., 1997, Lee and Montell, 1997, Kerber et al., 1996, BDGP Project Members, 1994-1999, O'Neill et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Forjanic et al., 1997, Lee and Montell, 1997, O'Neill et al., 1994)

Phenotype Manifest In

stomatogastric nervous system

(Forjanic et al., 1997)

Detailed Description

Statement

Reference

pnt¹²⁷⁷/pnt⁰⁷⁸²⁵ flies have normal eyes.

(Charroux et al., 2006)

Mispositioned ganglia, SNS is considerably reduced in size and defasciculated.

(Forjanic et al., 1997)

Clones in the eye are missing photoreceptors.

(O'Neill et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pnt[+]/pnt⁰⁷⁸²⁵ is an enhancer of visible phenotype of csw^lf

(Firth et al., 2000)

Suppressor of

Statement

Reference

pnt[+]/pnt⁰⁷⁸²⁵ is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

pnt⁰⁷⁸²⁵ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

NOT Suppressor of

Statement

Reference

pnt[+]/pnt⁰⁷⁸²⁵ is a non-suppressor of lethal | recessive | third instar larval stage phenotype of PolE1^pl10R

(Verma et al., 2012)

Other

Statement

Reference

Ras85D^V12.sev, pnt⁰⁷⁸²⁵, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

pnt¹²⁷⁷/pnt⁰⁷⁸²⁵ is an enhancer of ommatidium phenotype of Gug^UAS.cCa, Scer\GAL4^GMR.PF

(Charroux et al., 2006)

pnt[+]/pnt⁰⁷⁸²⁵ is an enhancer of ommatidium phenotype of csw^lf

(Firth et al., 2000)

pnt[+]/pnt⁰⁷⁸²⁵ is an enhancer of wing vein phenotype of csw^lf

(Firth et al., 2000)

Suppressor of

Statement

Reference

pnt[+]/pnt⁰⁷⁸²⁵ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

da², pnt[+]/pnt⁰⁷⁸²⁵ has follicle cell phenotype

(Smith et al., 2002)

da², pnt⁰⁷⁸²⁵ has follicle cell phenotype

(Smith et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnt⁰⁷⁸²⁵ complements the lethality seen in DNApol-ε^pl10R.

(Verma et al., 2012)

The rough eye phenotype of flies expressing Gug^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PF is enhanced in both a pnt¹²⁷⁷/pnt^Δ88 and a pnt¹²⁷⁷/pnt⁰⁷⁸²⁵ background.

(Charroux et al., 2006)

The csw^lf/Y rough eye and wing vein gap phenotypes are dominantly enhanced by pnt⁰⁷⁸²⁵.

(Firth et al., 2000)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by pnt⁰⁷⁸²⁵.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11724

ry⁵⁰⁶ P{PZ}pnt⁰⁷⁸²⁵/TM3, Sb¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Analysis of excess cardioblast phenotype provides an allelic series:pnt^S012309, pnt² > pnt^RR112, pnt^rM254 > pnt^Δ88, pnt⁰⁷⁸²⁵.

(Alvarez et al., 2003)

Complements: sec13⁰¹⁰³¹. Complements: cnc⁰⁵¹³⁴. Complements: cnc⁰⁵⁵⁶¹. Complements: l(3)rF149^rF149.

(BDGP Project Members, 1994-1999)

Wild type revertants have lost the P element insertion.

(O'Neill et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

07825

(Geng and MacDonald, 2007)

l(3)07825

(Spradling et al., 1999, Maixner et al., 1998)

l(3)07825⁰⁷⁸²⁵

l(3)7825

(Forjanic et al., 1997)

pnt⁰⁷⁸²⁵

(Charroux et al., 2006)

pnt⁷⁸²⁵

(Brumby et al., 2004, Smith et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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