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General Information
Symbol
Dmel\GugUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Charroux
FlyBase ID
FBal0196227
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Atro, Atro wt
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the entire open reading frame of Gug.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of GugScer\UAS.cCa in the adult eye under the control of Scer\GAL4ninaE.PT results in mild degeneration over time, characterised by loss of photoreceptor cells.

14 day old eyes from animals expressing GugScer\UAS.cCa under the control of Scer\GAL4GMR.PU display large autophagolysosomes in the degenerating photoreceptors. Many mitochondria show abnormal morphology, although they are hardly present in strongly degenerated tissue.

Expression of GugScer\UAS.cCa in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue.

Expression of GugScer\UAS.cCa in prospective wing vein tissue, driven by Scer\GAL4C-580, leads to a substantial loss of wing veins and a reduction in wing size.

Expression of GugScer\UAS.cCa under the control of Scer\GAL4dpp.blk1 causes fusion of the tarsus in the legs.

Expression of GugScer\UAS.cCa under the control of Scer\GAL4GMR.PF causes a rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of GugScer\UAS.cCa does not suppress the loss of ventral eye tissue caused by expression of mir-8SC1 under the control of Scer\GAL4ey.PH.

Expression of GugScer\UAS.cCa under the control of Scer\GAL4GMR.PU in Atg1Δ3D mutant eyes fails to rescue cell degeneration.

Expression of GugScer\UAS.cCa in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg5dsRNA.Scer\UAS.

Expression of GugScer\UAS.cCa in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of TorTED.Scer\UAS.

Expression of GugScer\UAS.cCa in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1GS10797.

Expression of GugScer\UAS.cCa, under the control of Scer\GAL4GMR.PF, suppresses the rough eye phenotype of rhohs.sev-expressing flies.

Expression of GugScer\UAS.cCa, under the control of Scer\GAL4GMR.PF, enhances the rough eye phenotype seen in flies that express argosGMR.PC.

Flies that coexpress GugScer\UAS.cCa and aopScer\UAS.cRa, under the control of Scer\GAL4GMR.PF, show an enhanced rough eye phenotype, compared to flies expressing either single transgene. The third instar discs of flies expressing both transgenes are normal, suggesting that the effects observed in the adult eyes occur during the pupal stage.

The rough eye phenotype of flies expressing GugScer\UAS.cCa under the control of Scer\GAL4GMR.PF is enhanced in both an pnt1277/pntΔ88 and an pnt1277/pnt07825 background.

Expression of either GugScer\UAS.cCa or aopScer\UAS.cRa has very little effect on the extra wing vein material produced in flies that overexpress btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4GMR.PF. However, this wing vein phenotype is suppressed when GugScer\UAS.cCa and aopScer\UAS.cRa are both expressed along with btl::EgfrScer\UAS.T:λ\cI-DD (all under the control of Scer\GAL4GMR.PF).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of GugdsRNA.1.Scer\UAS in the L3 and L4 inter-vein region under the control of Scer\GAL4dpp.blk1 results in ectopic wing vein formation, which is rescued by co-expression of GugScer\UAS.cCa.

Expression of GugdsRNA.2.Scer\UAS in the L3 and L4 inter-vein region under the control of Scer\GAL4dpp.blk1 results in ectopic wing vein formation, which is rescued by co-expression of GugScer\UAS.cCa.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
GugScer\UAS.cCa
GugUAS.cCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Charroux
Secondary FlyBase IDs
    References (6)