FlyBase Allele Report: Dmel\Gug[03928]

General Information

Symbol

Dmel\Gug⁰³⁹²⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0009495

Feature type

allele

Associated gene

Dmel\Gug

Associated Insertion(s)

P{PZ}Gug⁰³⁹²⁸

Carried in Construct

Also Known As

l(3)03928

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Gug⁰³⁹²⁸

Cytology

Description

The P{PZ} insertion is located within the first exon, within the 5' UTR.

(Zhang et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:8,450,397..8,450,397 [+]

(Charroux et al., 2006, Erkner et al., 2002, Zhang et al., 2002, Misra, 2000.8.25, Spradling et al., 1999, Nicholls and Gelbart, 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of dentatorubral-pallidoluysian atrophy

CEA with Gug^rO154a

(Zhang et al., 2002)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die during embryonic stage

(Charroux et al., 2006)

some die during embryonic stage

(Charroux et al., 2006)

Phenotype Manifest In

larval somatic muscle cell

(Dobi et al., 2014)

larval somatic muscle cell (with Df(3L)BSC389)

(Dobi et al., 2014)

Detailed Description

Statement

Reference

Homozygous stage 13-14 have the normal number of crystal cells.

(Milchanowski et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gug⁰³⁹²⁸ has lethal | embryonic stage | maternal effect phenotype, enhanceable by eve¹

(Zhang et al., 2002)

Gug⁰³⁹²⁸ has lethal | embryonic stage | maternal effect phenotype, enhanceable by eve²

(Zhang et al., 2002)

Gug⁰³⁹²⁸ has lethal | embryonic stage | maternal effect phenotype, enhanceable by eve³

(Zhang et al., 2002)

Gug⁰³⁹²⁸ has lethal | embryonic stage | maternal effect phenotype, enhanceable by eve⁴

(Zhang et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

Gug⁰³⁹²⁸/Gug[+] is an enhancer of wing vein | ectopic phenotype of rl^Sem

(Charroux et al., 2006)

Gug⁰³⁹²⁸/Gug[+] is an enhancer of interommatidial bristle phenotype of rho^hs.sev

(Charroux et al., 2006)

Gug⁰³⁹²⁸/Gug[+] is an enhancer of ommatidium phenotype of rho^hs.sev

(Charroux et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype seen when flies express one copy of rho^hs.sev is enhanced when these flies are heterozygous for Gug⁰³⁹²⁸.

The ectopic wing vein material phenotype of flies expressing rl^Sem is enhanced in Gug⁰³⁹²⁸ heterozygotes.

(Charroux et al., 2006)

Gug⁰³⁹²⁸ enhances the transformation of segments A5 to A4, A6 to A5 and A7 to A6 seen in Df(3R)P9/+ males. Gug⁰³⁹²⁸ enhances the transformation of haltere to wing seen in Df(3R)P9/+ animals.

(Kankel et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Gug⁰³⁹²⁸ is rescued by Gug^UAS.cCa/Scer\GAL4^arm.PS

(Charroux et al., 2006)

Gug⁰³⁹²⁸ is rescued by Gug^Ubi-p63E.GFP

(Charroux et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11615

P{PZ}Gug⁰³⁹²⁸ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Precise excision of the P{PZ} element can revert the mutant phenotype.

(Erkner et al., 2002)

Complements: h⁰¹⁶²⁰. Complements: h⁰²⁵³⁷. Complements: h⁰⁸²⁴⁷. Complements: cpo⁰⁸⁴³⁵. Complements: Prm¹⁰⁶³¹. Complements: Idh^L3852. Complements: foi^j8E8. Complements: foi^neo13. Complements: l(3)neo14¹. Complements: SrpRβ^rK561. Complements: SrpRβ^rL537. Complements: ergic53^s1760.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Atro⁰³⁹²⁸

(Kankel et al., 2004)

Atro^PZ3928

(Charroux et al., 2006)

Gug⁰³⁹²⁸

(Selvan et al., 2017, Dobi et al., 2014, Christensen et al., 2009.6.15, Christensen et al., 2007.10.29)

(Zhang et al., 2002)

l(3)03928

(Luschnig et al., 2004, Zhang et al., 2002, Misra, 2000.8.25, Spradling et al., 1999)

l(3)03928⁰³⁹²⁸

(Nicholls and Gelbart, 1998, BDGP Project Members, 1994-1999)

l(3)PZ3928

(Erkner et al., 2002)

l(3)PZGug³⁹²⁸

(Erkner et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

Open Close