FlyBase Allele Report: Dmel\Atg1[GS10797]

General Information

Symbol

Dmel\Atg1^GS10797

Species

D. melanogaster

Name

FlyBase ID

FBal0216676

Feature type

allele

Associated gene

Dmel\Atg1

Associated Insertion(s)

P{GSV6}Atg1^GS10797

Carried in Construct

Also Known As

UAS-Atg1^GS10797, UAS-Atg1, GS10797

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV6}Atg1^GS10797

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates dentatorubral-pallidoluysian atrophy

modeled by Gug^75QN.UAS

(Nisoli et al., 2010)

modeled by Gug^66QC.UAS

(Nisoli et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

abnormal eye color, with Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

decreased body weight, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

decreased cell size, with Scer\GAL4^Cg.PA

(Chang and Neufeld, 2009, Scott et al., 2007)

decreased size | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

decreased size | adult stage, with Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

increased cell death, with Scer\GAL4^Cg.PA

(Chang and Neufeld, 2009)

long lived, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

short lived | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

(Bjedov et al., 2020)

visible | adult stage, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

visible | adult stage, with Scer\GAL4^GMR.PU

(Braden and Neufeld, 2016)

Phenotype Manifest In

embryonic/larval fat body, with Scer\GAL4^Cg.PA

(Chang and Neufeld, 2009)

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

eye, with Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

eye, with Scer\GAL4^GMR.PU

(Braden and Neufeld, 2016)

fat body, with Scer\GAL4^Cg.PA

(Scott et al., 2007)

wing, with Scer\GAL4^Cyp6g1.HR

(Bjedov et al., 2020)

Detailed Description

Statement

Reference

Expression of Atg1^GS10797 under the control of Scer\GAL4^GMR.PU results in reduced adult eye size.

(Braden and Neufeld, 2016)

Expression of Atg1^GS10797 under the control of Scer\GAL4^Cg.PA results in the larval fat body being reduced in size and showing extensive cell death.

(Chang and Neufeld, 2009)

The salivary glands of wandering larvae expressing Atg1^GS10797 under the control of Scer\GAL4^fkh.PH are condensed and degraded compared to control glands at the same stage, and almost complete degradation of the glands is seen by 6 hours after puparium formation in animals expressing Atg1^GS10797 under the control of Scer\GAL4^fkh.PH.

(Berry and Baehrecke, 2007)

Expression of Atg1^GS10797 under the control of Scer\GAL4^Cg.PA results in variable reduction in cell size and induction of autophagy in the fat body.

(Scott et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Hsap\ZNRF2^UAS.cBa, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Hsap\ZNRF2^UAS.cBa, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by detr^UAS.EGFP, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by detr^UAS.EGFP, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Hsap\ZNRF1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Hsap\ZNRF1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Suppressed by

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has decreased size | adult stage phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^Cg.PA has increased cell death phenotype, suppressible by Atg13^unspecified

(Chang and Neufeld, 2009)

Atg1^GS10797, Scer\GAL4^Cg.PA has decreased cell size phenotype, suppressible by Rheb^{EP50.084-loxP}, Scer\GAL4^Cg.PA

(Scott et al., 2007)

NOT suppressed by

Statement

Reference

Atg1^GS10797, Scer\GAL4^Cg.PA has decreased cell size phenotype, non-suppressible by Atg13^unspecified

(Chang and Neufeld, 2009)

Enhancer of

Statement

Reference

Atg1^GS10797, Scer\GAL4^{elav.Switch.PO} is an enhancer of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

NOT Enhancer of

Statement

Reference

Atg1^GS10797, Scer\GAL4^{elav.Switch.PO} is a non-enhancer of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Atg1^GS10797, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Aduk^UAS.cBa, Scer\GAL4^GMR.PU

(Braden and Neufeld, 2016)

Suppressor of

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PFa is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

Atg1^GS10797, Scer\GAL4^GMR.PFa is a suppressor | partially of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

Atg1^GS10797/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Scer\GAL4^fkh.PH/Atg1^GS10797 is a suppressor | partially of increased cell number | pupal stage phenotype of Df(2R)BSC696/hrm^Δ1

(Velentzas et al., 2018)

NOT Suppressor of

Statement

Reference

Atg1^GS10797, Scer\GAL4^{elav.Switch.PO} is a non-suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Other

Statement

Reference

Atg1^GS10797, BacA\p35^UAS.cHa, Scer\GAL4^hs.PU has short lived phenotype

(Bjedov et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\ZNRF2^UAS.cBa, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by detr^UAS.EGFP, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\ZNRF1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Suppressed by

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PF has eye phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Atg1^GS10797, Scer\GAL4^fkh.PH has embryonic/larval salivary gland phenotype, suppressible by Atg12^RNAi.UAS, Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

Atg1^GS10797, Scer\GAL4^Cg.PA has fat body phenotype, suppressible by Rheb^{EP50.084-loxP}, Scer\GAL4^Cg.PA

(Scott et al., 2007)

NOT suppressed by

Statement

Reference

Atg1^GS10797, Scer\GAL4^fkh.PH has embryonic/larval salivary gland phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^fkh.PH

(Berry and Baehrecke, 2007)

Enhancer of

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^75QN.UAS, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

Atg1^GS10797, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^66QC.UAS, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

Atg1^GS10797, Scer\GAL4^GMR.PU is an enhancer of retina | temperature conditional phenotype of Gug^UAS.cCa, Scer\GAL4^GMR.PU

(Nisoli et al., 2010)

NOT Enhancer of

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Aduk^UAS.cBa, Scer\GAL4^GMR.PU

(Braden and Neufeld, 2016)

Suppressor of

Statement

Reference

Atg1^GS10797, Scer\GAL4^GMR.PFa is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

Scer\GAL4^fkh.PH/Atg1^GS10797 is a suppressor | partially of salivary gland | pupal stage phenotype of Df(2R)BSC696/hrm^Δ1

(Velentzas et al., 2018)

Scer\GAL4^fkh.PH/Atg1^GS10797 is a suppressor of salivary gland | pupal stage phenotype of ctp^G0371

(Batlevi et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced eye size observed in adult flies expressing Aduk^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PU is not further decreased by co-expression of Atg1^GS10797 (although Atg1^GS10797 expression on its own also leads to small eye phenotype).

(Braden and Neufeld, 2016)

Expression of Atg1^GS10797 in the salivary glands under the control of Scer\GAL4^fkh.PH in ctp^G0371 mutant animals eliminates the accumulation of protein inclusions in salivary gland cells.

(Batlevi et al., 2010)

Expression of Gug^Scer\UAS.cCa in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1^GS10797.

Expression of Gug^{66QC.Scer\UAS} in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1^GS10797.

Expression of Gug^{75QN.Scer\UAS} in the adult eye under the control of Scer\GAL4^GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1^GS10797.

(Nisoli et al., 2010)

Atg13^unspecified suppresses the cell death but not the reduction in cell size in the fat body caused by expression of Atg1^GS10797 under the control of Scer\GAL4^Cg.PA.

(Chang and Neufeld, 2009)

Co-expression of Atg12^{dsRNA.Scer\UAS} suppresses the premature degradation of the salivary glands that is seen in animals expressing Atg1^GS10797 under the control of Scer\GAL4^fkh.PH.

(Berry and Baehrecke, 2007)

The variable reduction in cell size and induction of autophagy in the fat body that is seen in animals expressing Atg1^GS10797 under the control of Scer\GAL4^Cg.PA is suppressed if the animals are also co-expressing Rheb^{EP50.084-loxP}.

(Scott et al., 2007)

Xenogenetic Interactions

Statement

Reference

The premature degradation of the salivary glands that is seen in animals expressing Atg1^GS10797 under the control of Scer\GAL4^fkh.PH is not suppressed by co-expression of BacA\p35^Scer\UAS.cHa.

(Berry and Baehrecke, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Atg1^GS10797

(Pérez et al., 2015, Chang and Neufeld, 2009, Berry and Baehrecke, 2007)

Atg1^GS1797

(Stratoulias and Heino, 2015)

Name Synonyms

Secondary FlyBase IDs

References (21)

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