FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gug66QC.UAS
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General Information
Symbol
Dmel\Gug66QC.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258446
Feature type
allele
Associated gene
Dmel\Gug
Associated Insertion(s)
Carried in Construct
P{UAS-Atro.66QC}
Key Links
Transgenic product class
trinucleotide_repeat_expansion
(Nisoli et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Nisoli et al., 2010)
Mutagen
in vitro construct
(Nisoli et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Atro.66QC}
Cytology
Description

UASt regulatory sequences drive expression of a modified form of Gug carrying a 66Q stretch at the C-terminal end.

(Nisoli et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gug
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  dentatorubral-pallidoluysian atrophy
      CEA
      (Nisoli et al., 2010)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  dentatorubral-pallidoluysian atrophy
      is exacerbated by Atg1GS10797
      (Nisoli et al., 2010)
      is exacerbated by mTorTED.UAS
      (Nisoli et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Gug66QC.Scer\UAS in the eye under the control of Scer\GAL4GMR.PU results in progressive depigmentation. At 14 days old, degenerating photoreceptor cells display large autophagosomes.

      Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4ninaE.PT results in degeneration, characterised by loss of photoreceptor cells.

      Expression of Gug66QC.Scer\UAS in the glia under the control of Scer\GAL4Eaat1.PR results in reduced animal viability.

      Expression of Gug66QC.Scer\UAS in the neurons under the control of Scer\GAL4elav.PU does not result in reduced animal viability.

      Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue.

      (Nisoli et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by Atg5RNAi.UAS, Scer\GAL4GMR.PU

      (Nisoli et al., 2010)

      Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by mTorTED.UAS, Scer\GAL4GMR.PU

      (Nisoli et al., 2010)

      Gug66QC.UAS, Scer\GAL4GMR.PU has retina | temperature conditional phenotype, enhanceable by Atg1GS10797, Scer\GAL4GMR.PU

      (Nisoli et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg5dsRNA.Scer\UAS.

      Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of TorTED.Scer\UAS.

      Expression of Gug66QC.Scer\UAS in the adult eye under the control of Scer\GAL4GMR.PU, aged at 29[o]C for 28 days, results in a significant degeneration of retinal tissue, which is enhanced by co-expression of Atg1GS10797.

      (Nisoli et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gug66QC.Scer\UAS
      Gug66QC.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)