FB2026_02 , released June 18, 2026
Allele: Dmel\LanB2d5A1
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General Information
Symbol
Dmel\LanB2d5A1
Species
D. melanogaster
Name
FlyBase ID
FBal0009736
Feature type
allele
Associated gene
Dmel\LanB2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Wolfstetter and Holz, 2012)
Mutagen
diepoxybutane
Progenitor genotype
Cytology
Description

Mutation in the coding sequence which introduces a frame shift starting at nucleotide position 2598. This changes amino acid residue 867 from Glu to Ala and introduces a stop codon at residue 868.

(Wolfstetter and Holz, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:9,620,892..9,620,892 [+]
Comment:

Reported as a frameshift mutation starting at nucleotide 2598 that results in a E867A amino acid change and a stop codon at position C868. Annotated by curator as a 4 base deletion (CGAG) starting in codon 866 that would lead to the reported amino acid changes.

(Wolfstetter and Holz, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die at the end of embryogenesis.

      LanB2d5A1 and LanB2knod/LanB2d5A1 stage 16 embryos have a one-chambered, "dumpling-shaped" midgut and often have local accumulations and gaps in the visceral muscles.

      LanB2knod/LanB2d5A1 embryos lack single somatic muscles at random positions. The ventral oblique muscles in the four anterior segments are not attached to their tendon sites or are completely missing.

      (Wolfstetter and Holz, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      LanB2d5A1 has larval somatic muscle cell phenotype, enhanceable by kon[+]/konNP7048

      (Wolfstetter and Holz, 2012)
      Enhancer of
      Statement
      Reference

      LanB2d5A1 is an enhancer of larval somatic muscle cell phenotype of TspD77

      (Wolfstetter and Holz, 2012)
      NOT Enhancer of
      Statement
      Reference

      LanB2d5A1/l(3)67BDb[+] is a non-enhancer of larval somatic muscle cell phenotype of konNP7048

      (Wolfstetter and Holz, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of LanB2d5A1 does not affect the somatic muscle defects of konNP7048 embryos.

      One copy of konNP7048 strongly enhances the somatic muscle defects of LanB2d5A1 embryos.

      (Wolfstetter and Holz, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Leicht.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      LanB22
      (Wolfstetter and Holz, 2012)
      LanB2d5A1
      l(3)67BDb1
      (Wolfstetter and Holz, 2012)
      l(3)67BDbd5A1
      (Leicht and Bonner, 1988)
      l(3)67Db1
      (Wolfstetter and Holz, 2012)
      l(3)d5A1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)