FB2026_02 , released June 18, 2026
Allele: Dmel\Notum72Da-1
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General Information
Symbol
Dmel\Notum72Da-1
Species
D. melanogaster
Name
FlyBase ID
FBal0009921
Feature type
allele
Associated gene
Dmel\Notum
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: W335term.

(Giraldez et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,030,329..16,030,329 [+]
Nucleotide change:

G16030329A

Amino acid change:

W335term | Notum-PA

Reported amino acid change:

W335term

Comment:

The Notum72Da-1 mutation was induced on the NotumEPg31259 chromosome which carries a P{EPg} insertion approximately 1kb upstream of Notum. Notum72Da-1 is a G to A nucleotide change at the second or third position of the wild type Trp codon leading to a nonsense mutation. (exact site of mutation unspecified). The mutation was annotated at the secon base of the codon.

(Giraldez et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Kennison.

      Separable from: separable lethal mutation. The original "Notum72Da-1" chromosome contains a second site lethal mutation, because flies homozygous for the chromosome are embryonic lethal, but hemizygotes carrying the "Notum72Da-1" chromosome over Df(3L)st-f13 or other Notum mutant alleles are larval-early-pupal lethal.

      (Giraldez, 2002.9.13)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Notum4
      (Giraldez, 2002.9.13, Giraldez et al., 2002)
      Notum72Da-1
      (Bivik et al., 2015)
      l(3)72Da
      (Giraldez et al., 2002)
      l(3)72Da1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)