FB2026_03 , released September 17, 2026
Allele: Dmel\l(3)mbn1
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General Information
Symbol
Dmel\l(3)mbn1
Species
D. melanogaster
Name
FlyBase ID
FBal0011021
Feature type
allele
Associated gene
Dmel\l(3)mbn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gateff, 1977)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Excessive proliferation of proplasmatocytes which show abnormal differentiation into giant plasmato-, lamello- and podocytes.

      (Dreschers et al., 1994)

      Larval blood cells show a malignant phenotype. Larval haematopoietic organs are enlarged, an increased number of undifferentiated plasmatocytes are released in the haemolymph, the neoplastic blood cells invade and destroy all larval tissues.

      (Becker et al., 1991)

      Lethal at the time of puparium formation. Mature larvae appear bloated, as they have 150 times as many free blood cells in their hemolymph as wild-type mature larvae, due to the steady production of immature plasmatocytes in the lymph glands. Most blood cells are immature round cells resembling plasmatocytes. A few blood cells are sickle-shaped. Podocytes are rarely observed and crystal cells are present in reduced numbers. The blood cells can encapsulate and melanise larval tissue. Larval tissues, such as the imaginal discs, fat body and muscles are destroyed by invasion of blood cells.

      (Gateff, 1977)

      pupariation lethal larvae appear bloated owing to having 150 times as many free hematocytes as normal; these can encapsulate and melanize larval tissue.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(3)mbn
      (Gateff, 1977)
      l(3)mbn1
      (Kúthy-Sutus et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)