FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lds3
Open Close
General Information
Symbol
Dmel\lds3
Species
D. melanogaster
Name
FlyBase ID
FBal0011610
Feature type
allele
Associated gene
Dmel\lds
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Girdham and Glover, 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ldshor-rvP2/lds3 males males are almost completely sterile. XX//X0 mosaics are not seen in the progeny of these males.

      XX//X0 mosaics are seen in the progeny of ldsHor-D/lds3 males at a low frequency.

      (Szalontai et al., 2009)

      100% penetrant maternal effect phenotype that is not subject to paternal rescue. Severe defects in cell division pathways and structure of the cell layers. Nuclear density is uneven at the syncytial embryo surface after nuclear migration and the regions devoid of nuclei contain "extra" centrosomes. Fail to separate chromatin at anaphase, can result in chromatin fragmentation. P element mediated transformation of the wild type lds gene restored fertility in homozygous females.

      (Girdham and Glover, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ldshor-rvP2

      (Szalontai et al., 2009)
      Rescued by

      lds3/ldshor-rvP2 is rescued by ldst5.1

      (Szalontai et al., 2009)
      Comments

      The sterility of ldshor-rvP2/lds3 females is rescued by ldst5.1.

      (Szalontai et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      lds098-1
      (Girdham and Glover, 1991)
      lds098
      (Tearle and Nusslein-Volhard, 1987)
      lds3
      lds98.1
      (Szalontai et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)