FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mocs11
Open Close
General Information
Symbol
Dmel\Mocs11
Species
D. melanogaster
Name
FlyBase ID
FBal0011742
Feature type
allele
Associated gene
Dmel\Mocs1
Associated Insertion(s)
Carried in Construct
Also Known As
lxd
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Schott et al., 1986, Keller and Glassman, 1964)
Progenitor genotype
Cytology
Description

Amino acid replacement: T304I.

(Ramin et al., 2019)

Nucleotide substitution: C?T.

(Ramin et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:11,072,219..11,072,219 [+]
Nucleotide change:

C11072219T

Reported nucleotide change:

C?T

Amino acid change:

T304I | Mocs1-PA; T304I | Mocs1-PC

Reported amino acid change:

T304I

(Ramin et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mocs11 homozygotes, Mocs1d03517/Mocs11 transheterozygotes and Mocs1f03019/Mocs11 transheterozygotes show severely impaired intermale aggression behavior (decreased number of lunges), as compared to controls.

      (Ramin et al., 2019)

      Homozygous flies have wild-type eyes on normal media and phenocopy ry (eyes are dullish red-brown) when reared on allopurinol.

      (Schott et al., 1986)

      20% of homozygous flies have brown eyes, the penetrance of this phenotype is increased by dietary tungstate.

      (Bentley et al., 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Homozygous flies have only 25% of the ry enzyme activity found in wild-type strains and have no pyridoxal oxidase activity.

      (Keller and Glassman, 1964)

      Feeding lxd1 flies with tungstate results in a dose-dependent reduction in ry and Aldox-1 enzyme activity which is greater than that seen for wild-type flies.

      (Bentley et al., 1981)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mocs11
      lxd
      (Bentley et al., 1981, Keller and Glassman, 1964)
      lxd1
      mocs11
      (Ramin et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)