Associated with a large insertion in the second exon and a small deletion that removes a portion of the 5'-UTR and the first six amino acids of LKRSDH. Mutants exhibit an 80% decrease in transcript levels as compared with controls.
A complex event involving deletion and insertion of sequences that removes the region around the LKRSDH ATG codon. The inserted sequence is ctgcgcgcaaca.....cacccgatgactggggaatgctgaaatcag where ... indicates a repetitive sequence.
Larvae, pupae and adults contain a higher concentration of lysine than wild type. Accumulation of lysine is postulated to result from a block in its degradation. Flies homozygous for lys1 occasionally have faintly reddish fat cells, especially in the thorax. This effect enhanced by starvation, or by combining lys1 with rc1, rc2, or cho1. RK3.
