FlyBase Allele Report: Dmel\VhaAC39-1[cho-1]

General Information

Symbol

Dmel\VhaAC39-1^cho-1

Species

D. melanogaster

Name

FlyBase ID

FBal0001639

Feature type

allele

Associated gene

Dmel\VhaAC39-1

Associated Insertion(s)

Carried in Construct

Also Known As

cho¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Sturtevant, 1955)

Progenitor genotype

Cytology

Description

Amino acid replacement: W330L.

(Grant et al., 2016)

Nucleotide coordinate is from chromosome X (r6).

(Grant et al., 2016)

Nucleotide substitution: G3882405T.

(Grant et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:3,882,405..3,882,405 [+]

Nucleotide change:

G3882405T

Amino acid change:

W330L | VhaAC39-1-PA

Reported amino acid change:

W330L

(Grant et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Sturtevant, 1955)

abnormal eye color (with VhaAC39-1^cho-2)

(Sturtevant, 1955)

fertile

(Sturtevant, 1955)

viable

(Sturtevant, 1955)

Phenotype Manifest In

Malpighian tubule

(Lindsley and Grell, 1968)

pigment cell

(Sturtevant, 1955)

pigment cell (with VhaAC39-1^cho-2)

(Sturtevant, 1955)

Detailed Description

Statement

Reference

RK1. Malpighian tubule colour: contain brown pigment; like red¹.

(Lindsley and Grell, 1968)

Eye colour: brown with whitish highlight. Paler than se¹, less purplish than pn¹. The eye colour phenotype is autonomous in mosaics (derived from ncd¹). Malpighian tubule colour: bright yellow, like wild-type. Testis colour: bright yellow, like wild-type. Eye colour: cho¹/cho² eye colour is indistinguishable from either cho¹ or cho².

(Sturtevant, 1955)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

VhaAC39-1^cho-1, v¹ has abnormal eye color phenotype

(Sturtevant, 1955)

Phenotype Manifest In

Enhancer of

Statement

Reference

VhaAC39-1^cho-1 is an enhancer of fat body phenotype of LKRSDH¹

Other

Statement

Reference

VhaAC39-1^cho-1, v¹ has pigment cell phenotype

(Sturtevant, 1955)

Additional Comments

Genetic Interactions

Statement

Reference

Malpighian tubule colour: no brown pigment with v¹. Malpighian tubule colour: no brown pigment with cn¹. Malpighian tubule colour: no brown pigment with st¹.

(Lindsley and Grell, 1968)

Eye colour: cho¹ g¹ eye colour is indistinguishable from g¹. Eye colour: yellowish, with v¹.

(Sturtevant, 1955)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4,303)